Ashe J, Georgopoulos A P
Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417.
Cereb Cortex. 1994 Nov-Dec;4(6):590-600. doi: 10.1093/cercor/4.6.590.
The relations of ongoing single-cell activity in the arm area of the motor cortex and area 5 to parameters of evolving arm movements in two-dimensional (2D) space were investigated. A multiple linear regression model was used in which the ongoing impulse activity of cells at time t + tau was expressed as a function of the (X, Y) components of the target direction and of position, velocity, and acceleration of the hand at time t, where tau was a time shift (-200 to +200 msec). Analysis was done on 290 cells in the motor cortex and 207 cells in area 5. The time shift at which the highest coefficient of determination (R2) was observed was determined and the statistical significance of the model tested. The median R2 was 0.581 and 0.530 for motor cortex and area 5, respectively. The median shift at which the highest R2 was observed was -90 and +30 msec for motor cortex and area 5, respectively. For most cells statistically significant relations were observed to all four parameters tested; most prominent were the relations to target direction and least prominent those to acceleration.
研究了运动皮层臂区和5区中正在进行的单细胞活动与二维（2D）空间中不断演变的手臂运动参数之间的关系。使用了多元线性回归模型，其中时间t + τ时细胞的持续冲动活动表示为目标方向的（X，Y）分量以及时间t时手的位置、速度和加速度的函数，其中τ是时间偏移（-200至+200毫秒）。对运动皮层中的290个细胞和5区中的207个细胞进行了分析。确定了观察到最高决定系数（R2）时的时间偏移，并测试了模型的统计显著性。运动皮层和5区的R2中位数分别为0.581和0.530。运动皮层和5区观察到最高R2时的中位数偏移分别为-90和+30毫秒。对于大多数细胞，观察到与所有四个测试参数都存在统计学上显著的关系；最显著的是与目标方向的关系，最不显著的是与加速度的关系。
