Zeiss C R, Lockey R F
J Allergy Clin Immunol. 1976 May;57(5):440-8. doi: 10.1016/0091-6749(76)90059-2.
Oral aspirin challenge was used to detect unrecognized aspirin intolerance in a select group of 50 asthmatic patients who denied aspirin intolerance. A double-blind protocol was used to further study those patients who reacted to initial graded aspirin challenge. In one patient the use of a double-blind protocol led to the serendipitous discovery of a 72-hr refractory period to the adverse effects of aspirin, after initial ingestion of aspirin resulted in respiratory and systemic symptoms.
口服阿司匹林激发试验用于检测一组选定的50名否认阿司匹林不耐受的哮喘患者中未被识别的阿司匹林不耐受情况。采用双盲方案进一步研究那些对初始分级阿司匹林激发试验有反应的患者。在一名患者中，在初始摄入阿司匹林导致呼吸和全身症状后，使用双盲方案意外发现了对阿司匹林不良反应的72小时不应期。
