人体受试者摄入单一剂量及联合剂量后β-胡萝卜素和角黄素的药代动力学。
Pharmacokinetics of beta-carotene and canthaxanthin after ingestion of individual and combined doses by human subjects.
作者信息
White W S, Stacewicz-Sapuntzakis M, Erdman J W, Bowen P E
机构信息
Division of Nutritional Sciences, University of Illinois, Urbana-Champaign.
出版信息
J Am Coll Nutr. 1994 Dec;13(6):665-71. doi: 10.1080/07315724.1994.10718463.
OBJECTIVE
This study investigated effects of ingestion of a combined dose of beta-carotene and canthaxanthin on their individual pharmacokinetics in serum.
METHODS
During three 5-day study periods, two subjects ingested either a 25 mg dose of beta-carotene, a 25 mg dose of canthaxanthin, or a combined dose of 25 mg each of beta-carotene and canthaxanthin. Pharmacokinetics of the individual and combined doses were compared within subjects.
RESULTS
Ingestion of a concurrent beta-carotene dose reduced the peak serum canthaxanthin concentration by 38.8 +/- 6.5%, and the 24- and 72-hour areas under the serum canthaxanthin concentration-time curves by 38.1 +/- 6.4 and 34.4 +/- 7.4%, respectively. The suggested antagonism between beta-carotene and canthaxanthin was not reciprocal; beta-carotene inhibited the appearance of canthaxanthin in serum but canthaxanthin did not inhibit the appearance of beta-carotene.
CONCLUSION
Our data suggest that ingestion of a combined pharmacologic dose of beta-carotene and canthaxanthin reduces the bioavailability of the canthaxanthin dose.
目的
本研究调查了联合服用β-胡萝卜素和角黄素对它们在血清中各自药代动力学的影响。
方法
在三个为期5天的研究阶段，两名受试者分别服用25毫克剂量的β-胡萝卜素、25毫克剂量的角黄素，或β-胡萝卜素和角黄素各25毫克的联合剂量。在受试者体内比较单独服用和联合服用剂量的药代动力学。
结果
同时服用β-胡萝卜素剂量使血清角黄素峰值浓度降低了38.8±6.5%，使血清角黄素浓度-时间曲线下24小时和72小时的面积分别降低了38.1±6.4%和34.4±7.4%。β-胡萝卜素和角黄素之间的拮抗作用并非相互的；β-胡萝卜素抑制了角黄素在血清中的出现，但角黄素并未抑制β-胡萝卜素的出现。
结论
我们的数据表明，联合服用药理剂量的β-胡萝卜素和角黄素会降低角黄素剂量的生物利用度。
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