Yamada S, Sakakibara H, Futatsuka M, Harada N, Nakamoto M
Department of Public Health, Nagoya University School of Medicine, Japan.
Nagoya J Med Sci. 1994 May;57 Suppl:49-57.
From data collected in 1966, 1973, 1986 and 1989, we analyzed the correlations among examination findings, subjective symptoms, stages in the disorder of vibration syndrome and vibration exposure. As vibration syndrome progressed and vibration exposure accumulated, abnormality of examination findings, the prevalence of vibration induced white finger (VWF), numbness (N) and other subjective symptoms increased. Abnormality of examination findings and prevalence of subjective symptoms in the VWF(+) N(+) group were greatly different from those in the VWF(-) N(-) group. Both findings and symptoms showed closer correlations with VWF(+) than with N(+). Stages in the disorder traced the progression from VWF(-)N(-) to VWF(-)N(+), then to VWF(+)N(+/-), and finally to VWF(+/++)N(+/++). Pathophysiologically, it seems that VWF(+) and N(+) relayed many more cold and pain signals from the hand to the central nervous system. Such signals may activate autonomic nervous activity. In the recovery, subjective symptoms correlated more closely with N(+) than with VWF(+). This is because VWF involves the autonomic nervous system's hyperactivity and hypersensitivity to cold, both of which subside gradually in the recovery; N, however, involves pathological changes in nerve tissue which are irreversible.
根据1966年、1973年、1986年和1989年收集的数据,我们分析了检查结果、主观症状、振动综合征病情阶段与振动暴露之间的相关性。随着振动综合征的进展以及振动暴露的累积,检查结果异常、振动性白指(VWF)患病率、麻木(N)及其他主观症状均有所增加。VWF(+)N(+)组的检查结果异常和主观症状患病率与VWF(-)N(-)组有很大差异。检查结果和症状与VWF(+)的相关性均比与N(+)的相关性更强。病情阶段呈现从VWF(-)N(-)到VWF(-)N(+),再到VWF(+)N(+/-),最后到VWF(+/++)N(+/++)的进展过程。从病理生理学角度来看,似乎VWF(+)和N(+)会将更多来自手部的冷和痛信号传递至中枢神经系统。此类信号可能会激活自主神经活动。在恢复过程中,主观症状与N(+)的相关性比与VWF(+)的相关性更强。这是因为VWF涉及自主神经系统的活动亢进和对寒冷的超敏反应,二者在恢复过程中会逐渐消退;而N则涉及神经组织的不可逆病理变化。