Hermann B P, Seidenberg M, Dohan F C, Wyler A R, Haltiner A, Bobholz J, Perrine A
Epi-Care Center (BPH), Baptist Memorial Hospital, Memphis, Tennessee.
Neurosurgery. 1995 Jan;36(1):39-44; discussion 44-5. doi: 10.1227/00006123-199501000-00004.
Memory decline represents the primary neuropsychological morbidity of anterior temporal lobectomy. Recent investigations using laboratory tests of memory have reported an association between the neuropathological status of the resected left mesial temporal region and memory outcome, with adverse memory outcome associated with a lack of significant left hippocampal pathology. The purpose of this investigation was to examine the relationship between the reports by the patients and their families of observed postoperative changes in day-to-day memory function and the degree of hippocampal sclerosis in resected left mesial temporal lobes. Twenty patients and a close family member (parent or spouse) of each of the patients completed standardized questionnaires assessing pre- to postoperative changes in verbal and spatial memory; these were related to the neuropathological findings. The results indicated that patients without left hippocampal sclerosis reported significantly worse memory outcome than those with hippocampal sclerosis. The ratings provided by the relatives of the patients yielded a comparable effect, and objective memory tests supported the reports by the patients and their families. The neuropsychological findings associated with left hippocampal pathology are of clinical significance and should be considered in surgical evaluation and in the counseling process.
记忆衰退是颞叶前部切除术主要的神经心理学发病表现。近期利用记忆实验室测试的研究报告称，切除的左侧内侧颞叶区域的神经病理学状态与记忆结果之间存在关联，不良记忆结果与左侧海马体缺乏明显病变相关。本研究的目的是检验患者及其家属报告的术后日常记忆功能变化与切除的左侧内侧颞叶海马硬化程度之间的关系。20名患者及其每位患者的一名近亲（父母或配偶）完成了标准化问卷，评估术前到术后言语和空间记忆的变化；这些变化与神经病理学发现相关。结果表明，没有左侧海马硬化的患者报告的记忆结果比有海马硬化的患者明显更差。患者亲属给出的评分产生了类似的效果，客观记忆测试支持了患者及其家属的报告。与左侧海马体病变相关的神经心理学发现具有临床意义，在手术评估和咨询过程中应予以考虑。
