Grunwald T, Lehnertz K, Heinze H J, Helmstaedter C, Elger C E
Department of Epileptology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3193-7. doi: 10.1073/pnas.95.6.3193.
Animal studies and neuropsychological tests of patients with temporal lobe epilepsy have demonstrated the importance of human medial temporal lobes for memory formation. In addition, more recent studies have shown that the human hippocampal region is also involved in novelty detection. However, the exact contribution of the hippocampus proper to these processes is still unknown. To examine further its role we compared event-related potentials recorded within the medial temporal lobes in 29 temporal lobe epilepsy patients with and 21 without hippocampal sclerosis. While in patients with extrahippocampal lesions but without hippocampal sclerosis event-related potentials to first presentations and repetitions of words were reduced on the side of the epileptogenic focus, in patients with hippocampal sclerosis only those to first presentations but not to repetitions were affected. Because sclerosis of the hippocampus proper selectively reduced event-related potentials to new but not old verbal stimuli, it can be concluded that the human hippocampus proper contributes to verbal novelty detection.
对颞叶癫痫患者的动物研究和神经心理学测试表明，人类内侧颞叶对记忆形成具有重要性。此外，最近的研究表明，人类海马区也参与新奇性检测。然而，海马体本身对这些过程的确切贡献仍然未知。为了进一步研究其作用，我们比较了29例有海马硬化和21例无海马硬化的颞叶癫痫患者在内侧颞叶记录的事件相关电位。在没有海马硬化的海马体外病变患者中，致痫灶一侧对单词首次呈现和重复的事件相关电位降低，而在有海马硬化的患者中，仅对首次呈现而非重复的事件相关电位受到影响。由于海马体本身的硬化选择性地降低了对新的而非旧的言语刺激的事件相关电位，因此可以得出结论，人类海马体本身有助于言语新奇性检测。
