Aoki I, Kinzer C, Shirai A, Paul W E, Klinman D M
Retroviral Immunology Section, Food and Drug Administration, Bethesda, MD 20892, USA.
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2534-8. doi: 10.1073/pnas.92.7.2534.
The phenotype and antigenic specificity of cells secreting interleukin (IL) 4, IL-6, and interferon gamma was studied in mice during primary and secondary immune responses. T lymphocytes were the major source of interferon gamma, whereas non-B/non-T cells were the dominant source of IL-4 and IL-6 in the spleens of immunized animals. Cytokine-secreting non-B/non-T cells expressed surface receptors for IgE and/or IgG types II/III. Exposing these cells to antigen-specific IgE or IgG in vivo (or in vitro) "armed" them to release IL-4 and IL-6 upon subsequent antigenic challenge. These findings suggest that non-B/non-T cells may represent the "natural immunity" analogue of CD4+ T helper type 2 cells and participate in a positive feedback loop involved in the perpetuation of T helper type 2 cell responses.
在初次和二次免疫反应期间，对小鼠体内分泌白细胞介素（IL）-4、IL-6和干扰素γ的细胞的表型和抗原特异性进行了研究。T淋巴细胞是干扰素γ的主要来源，而在免疫动物的脾脏中，非B/非T细胞是IL-4和IL-6的主要来源。分泌细胞因子的非B/非T细胞表达IgE和/或II/III型IgG的表面受体。在体内（或体外）将这些细胞暴露于抗原特异性IgE或IgG会“武装”它们，使其在随后受到抗原攻击时释放IL-4和IL-6。这些发现表明，非B/非T细胞可能代表CD4 + 2型辅助性T细胞的“天然免疫”类似物，并参与了与2型辅助性T细胞反应持续存在有关的正反馈回路。
