Bässler R
Institut für Pathologie, Mamma-Register, Städtisches Klinikum Fulda.
Praxis (Bern 1994). 1995 Mar 28;84(13):366-73.
The histopathologic diagnosis with the description of the size of the tumor, its growth pattern, grading, lymph node involvement, hormonal receptor status and pTNM-classification are basic requirements the treatment of breast cancer. In addition to the conventional methods new bio- or immunohistochemical factors can be determined, which have variable predictive values. The pTNM-classification is essential for the evaluation of clinical treatment results and prognosis. This histopathologic survey summarizes frequent and rare types of breast cancer, of which about 24 entities and 22 subtypes are known. The clinically important criteria of the intraductal carcinoma and of the lobular carcinoma in situ are described and their differentiation forms are mentioned. This review will illustrate the development in the detailed histopathologic diagnosis of breast cancer. Finally some aspects of lymphatic spread are outlined and the incidence and the sits of metastases.
乳腺癌治疗的基本要求包括组织病理学诊断以及对肿瘤大小、生长模式、分级、淋巴结受累情况、激素受体状态和pTNM分期的描述。除了传统方法外，还可测定新的生物或免疫组化因子，其预测价值各不相同。pTNM分期对于评估临床治疗效果和预后至关重要。本组织病理学综述总结了常见和罕见的乳腺癌类型，已知约有24种实体和22种亚型。描述了导管内癌和小叶原位癌的临床重要标准，并提及了它们的分化形式。本综述将阐述乳腺癌详细组织病理学诊断的发展情况。最后概述了淋巴转移的一些方面以及转移的发生率和部位。
