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流感病毒适应小鼠过程中M1蛋白的特异性变化。

Specific changes in the M1 protein during adaptation of influenza virus to mouse.

作者信息

Ward A C

机构信息

Biomolecular Research Institute, Parkville, Victoria, Australia.

出版信息

Arch Virol. 1995;140(2):383-9. doi: 10.1007/BF01309872.

DOI:10.1007/BF01309872
PMID:7710364
Abstract

The matrix (M) gene of influenza virus has been implicated as a determinant of virulence for mouse brain and lung. Comparison of the M gene sequences of the mouse brain adapted variants A/NWS/33 and A/WSN/33 to their parent, A/WS/33, identified two specific amino acid substitutions in the M1 protein which correlated with virulence for mouse: Ala41-->Val and Thr139-->Ala.

摘要

流感病毒的基质（M）基因已被认为是小鼠脑和肺毒力的决定因素。将适应小鼠脑的变异株A/NWS/33和A/WSN/33的M基因序列与其亲本A/WS/33进行比较，在M1蛋白中鉴定出两个与小鼠毒力相关的特定氨基酸取代：Ala41→Val和Thr139→Ala。

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