丝状流感病毒
Filamentous influenza viruses.
作者信息
Dadonaite Bernadeta, Vijayakrishnan Swetha, Fodor Ervin, Bhella David, Hutchinson Edward C
机构信息
Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, UK.
MRC-University of Glasgow Centre for Virus Research, University of Glasgow, 464 Bearsden Rd, Bearsden, Glasgow, Lanarkshire G61 1QH, UK.
出版信息
J Gen Virol. 2016 Aug;97(8):1755-1764. doi: 10.1099/jgv.0.000535. Epub 2016 Jun 30.
Abstract
Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely long filamentous virions. In contrast, strains of influenza that have adapted to laboratory growth typically produce only spherical virions. As a result, the filamentous phenotype has been overlooked in most influenza virus research. Recent advances in imaging and improved animal models have highlighted the distinct structure and functional relevance of filamentous virions. In this review we summarize what is currently known about these strikingly elongated virus particles and discuss their possible roles in clinical infections.
摘要
流感病毒的临床分离株会产生多形性病毒颗粒，包括极长的丝状病毒粒子。相比之下，适应实验室培养的流感毒株通常只产生球形病毒粒子。因此，丝状表型在大多数流感病毒研究中被忽视了。成像技术的最新进展和改良的动物模型突出了丝状病毒粒子独特的结构和功能相关性。在这篇综述中，我们总结了目前对这些显著拉长的病毒颗粒的了解，并讨论了它们在临床感染中可能发挥的作用。
相似文献
1
Filamentous influenza viruses.丝状流感病毒
J Gen Virol. 2016 Aug;97(8):1755-1764. doi: 10.1099/jgv.0.000535. Epub 2016 Jun 30.
2
Characterization of the host cell entry of filamentous influenza virus.丝状流感病毒宿主细胞进入过程的特征描述。
Arch Virol. 2005 Sep;150(9):1783-96. doi: 10.1007/s00705-005-0558-1. Epub 2005 Jun 15.
3
Single-particle measurements of filamentous influenza virions reveal damage induced by freezing.单颗粒测量丝状流感病毒粒子揭示了冷冻诱导的损伤。
J Gen Virol. 2019 Dec;100(12):1631-1640. doi: 10.1099/jgv.0.001330.
4
Structural Analysis of the Roles of Influenza A Virus Membrane-Associated Proteins in Assembly and Morphology.甲型流感病毒膜相关蛋白在组装和形态形成中作用的结构分析
J Virol. 2015 Sep;89(17):8957-66. doi: 10.1128/JVI.00592-15. Epub 2015 Jun 17.
5
The genetics of virus particle shape in equine influenza A virus.马流感病毒粒子形态的遗传学研究。
Influenza Other Respir Viruses. 2013 Dec;7 Suppl 4(Suppl 4):81-9. doi: 10.1111/irv.12197.
6
Filament-producing mutants of influenza A/Puerto Rico/8/1934 (H1N1) virus have higher neuraminidase activities than the spherical wild-type.甲型流感病毒/波多黎各/8/1934（H1N1）丝状生产突变体的神经氨酸酶活性高于球形野生型。
PLoS One. 2014 Nov 10;9(11):e112462. doi: 10.1371/journal.pone.0112462. eCollection 2014.
7
Formation of wild-type and chimeric influenza virus-like particles following simultaneous expression of only four structural proteins.仅同时表达四种结构蛋白后野生型和嵌合型流感病毒样颗粒的形成
J Virol. 2001 Jul;75(13):6154-65. doi: 10.1128/JVI.75.13.6154-6165.2001.
8
[Sedimentation characteristics of the virions and subviral particles of influenza C viruses].
Vopr Virusol. 1984 Nov-Dec;29(6):687-91.
9
[Structural study of influenza A virus virions using cryogenic methods].
Vopr Virusol. 1983 Nov-Dec;28(6):723-6.
10
Influenza virus morphogenesis and budding.流感病毒的形态发生与出芽
Virus Res. 2009 Aug;143(2):147-61. doi: 10.1016/j.virusres.2009.05.010. Epub 2009 May 27.
引用本文的文献
1
Quantitative Analysis of Virus Adsorption and Co-adsorption Behavior Using BET Modeling and SERS Spectroscopy.使用BET模型和表面增强拉曼光谱对病毒吸附和共吸附行为进行定量分析。
J Phys Chem A. 2025 Sep 4;129(35):8204-8219. doi: 10.1021/acs.jpca.5c03375. Epub 2025 Aug 24.
2
A New Approach for Respiratory Droplet Trajectory: Implications for Viral and Bacterial Disease Transmission in Emergency Departments.一种呼吸道飞沫轨迹的新方法：对急诊科病毒和细菌疾病传播的影响
Yonago Acta Med. 2025 Jul 24;68(3):197-208. doi: 10.33160/yam.2025.08.004. eCollection 2025 Aug.
3
Virion motility of sialoglycan-cleaving respiratory viruses.唾液酸聚糖裂解性呼吸道病毒的病毒粒子运动性
Npj Viruses. 2025 Jul 28;3(1):59. doi: 10.1038/s44298-025-00140-x.
4
Morphology-dependent entry kinetics and spread of influenza A virus.甲型流感病毒形态依赖的进入动力学与传播
EMBO J. 2025 Jun 9. doi: 10.1038/s44318-025-00481-6.
5
Influenza filaments: a graveyard of postdocs no longer?流感丝状病毒：不再是博士后的“坟墓”了吗？
EMBO J. 2025 Jun 9. doi: 10.1038/s44318-025-00480-7.
6
Induction of tunnelling nanotube-like structures by influenza A viruses requires the onset of apoptosis.甲型流感病毒诱导隧道纳米管样结构的形成需要细胞凋亡的发生。
PLoS Pathog. 2025 Jun 5;21(6):e1013191. doi: 10.1371/journal.ppat.1013191. eCollection 2025 Jun.
7
Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium.黏液在物理上限制甲型流感病毒颗粒接触上皮细胞。
Adv Biol (Weinh). 2025 Apr;9(4):e2400329. doi: 10.1002/adbi.202400329. Epub 2025 Feb 12.
8
Purification of Influenza Virions.流感病毒粒子的纯化
Methods Mol Biol. 2025;2890:27-51. doi: 10.1007/978-1-0716-4326-6_2.
9
Understanding Influenza.了解流感
Methods Mol Biol. 2025;2890:1-26. doi: 10.1007/978-1-0716-4326-6_1.
10
A physical model for M1-mediated influenza A virus assembly.M1介导的甲型流感病毒组装的物理模型。
Biophys J. 2025 Jan 7;124(1):134-144. doi: 10.1016/j.bpj.2024.11.016. Epub 2024 Nov 20.
本文引用的文献
1
Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection.单细胞分析与随机建模揭示甲型流感病毒感染中细胞间存在巨大变异性。
Nat Commun. 2015 Nov 20;6:8938. doi: 10.1038/ncomms9938.
2
Structural Analysis of the Roles of Influenza A Virus Membrane-Associated Proteins in Assembly and Morphology.甲型流感病毒膜相关蛋白在组装和形态形成中作用的结构分析
J Virol. 2015 Sep;89(17):8957-66. doi: 10.1128/JVI.00592-15. Epub 2015 Jun 17.
3
Novel thogotovirus associated with febrile illness and death, United States, 2014.2014年，美国出现与发热性疾病及死亡相关的新型托高土病毒。
Emerg Infect Dis. 2015 May;21(5):760-4. doi: 10.3201/eid2105.150150.
4
Identification of morphological differences between avian influenza A viruses grown in chicken and duck cells.鉴定在鸡和鸭细胞中生长的禽流感 A 病毒之间的形态差异。
Virus Res. 2015 Mar 2;199:9-19. doi: 10.1016/j.virusres.2015.01.005. Epub 2015 Jan 19.
5
Influenza A virus uses intercellular connections to spread to neighboring cells.甲型流感病毒利用细胞间连接扩散至邻近细胞。
J Virol. 2015 Feb;89(3):1537-49. doi: 10.1128/JVI.03306-14. Epub 2014 Nov 26.
6
Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility.甲型流感病毒核蛋白选择性降低神经氨酸酶基因节段的包装，同时增强病毒适应性和传播性。
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16854-9. doi: 10.1073/pnas.1415396111. Epub 2014 Nov 10.
7
Filament-producing mutants of influenza A/Puerto Rico/8/1934 (H1N1) virus have higher neuraminidase activities than the spherical wild-type.甲型流感病毒/波多黎各/8/1934（H1N1）丝状生产突变体的神经氨酸酶活性高于球形野生型。
PLoS One. 2014 Nov 10;9(11):e112462. doi: 10.1371/journal.pone.0112462. eCollection 2014.
8
A beneficiary role for neuraminidase in influenza virus penetration through the respiratory mucus.神经氨酸酶在流感病毒穿透呼吸道黏液过程中的有益作用。
PLoS One. 2014 Oct 15;9(10):e110026. doi: 10.1371/journal.pone.0110026. eCollection 2014.
9
Conserved and host-specific features of influenza virion architecture.流感病毒粒子结构的保守特征及宿主特异性特征
Nat Commun. 2014 Sep 16;5:4816. doi: 10.1038/ncomms5816.
10
Residue 41 of the Eurasian avian-like swine influenza a virus matrix protein modulates virion filament length and efficiency of contact transmission.欧亚禽源样猪流感病毒基质蛋白的41位残基调节病毒粒子的丝状体长度和接触传播效率。
J Virol. 2014 Jul;88(13):7569-77. doi: 10.1128/JVI.00119-14. Epub 2014 Apr 23.
Zotero 插件