Dadonaite Bernadeta, Vijayakrishnan Swetha, Fodor Ervin, Bhella David, Hutchinson Edward C
Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, UK.
MRC-University of Glasgow Centre for Virus Research, University of Glasgow, 464 Bearsden Rd, Bearsden, Glasgow, Lanarkshire G61 1QH, UK.
J Gen Virol. 2016 Aug;97(8):1755-1764. doi: 10.1099/jgv.0.000535. Epub 2016 Jun 30.
Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely long filamentous virions. In contrast, strains of influenza that have adapted to laboratory growth typically produce only spherical virions. As a result, the filamentous phenotype has been overlooked in most influenza virus research. Recent advances in imaging and improved animal models have highlighted the distinct structure and functional relevance of filamentous virions. In this review we summarize what is currently known about these strikingly elongated virus particles and discuss their possible roles in clinical infections.
流感病毒的临床分离株会产生多形性病毒颗粒，包括极长的丝状病毒粒子。相比之下，适应实验室培养的流感毒株通常只产生球形病毒粒子。因此，丝状表型在大多数流感病毒研究中被忽视了。成像技术的最新进展和改良的动物模型突出了丝状病毒粒子独特的结构和功能相关性。在这篇综述中，我们总结了目前对这些显著拉长的病毒颗粒的了解，并讨论了它们在临床感染中可能发挥的作用。
