短期血糖变化对胰岛素依赖型糖尿病患者视觉通路功能的影响
Effect of short term changes in blood glucose on visual pathway function in insulin dependent diabetes.
作者信息
Hardy K J, Scase M O, Foster D H, Scarpello J H
机构信息
Department of Endocrinology and Diabetes, North Staffordshire Royal Infirmary, Stoke-on-Trent.
出版信息
Br J Ophthalmol. 1995 Jan;79(1):38-41. doi: 10.1136/bjo.79.1.38.
BACKGROUND
Visual pathway function is abnormal in patients with insulin dependent diabetes mellitus (IDDM) without retinopathy, yet the mechanism underlying this abnormality is unknown. It is hypothesised that short term changes in blood glucose level affect visual pathway function in IDDM.
METHODS
Colour discrimination was measured in 10 uncomplicated aretinopathic IDDM patients during hyperinsulinaemic clamp, with the Farnsworth Munsell 100 hue test (100 hue test). After stable euglycaemia, patients were made hyperglycaemic (14 mmol/l), maintained euglycaemic (5 mmol/l), and rendered hypoglycaemic (2.5 mmol/l), in random order, on separate occasions at least 1 week apart.
RESULTS
Short term (1-2 hours) changes in blood glucose did not affect colour discrimination: mean (SD) 100 hue error score at 2.5 mmol/l was 34 (22) compared with 35 (33) at 5 mmol/l, and 39 (28) at 14 mmol/l.
CONCLUSION
These data suggest that short term (1-2 hours) changes in blood glucose are not the mechanism for visual pathway dysfunction in aretinopathic IDDM patients.
背景
无视网膜病变的胰岛素依赖型糖尿病（IDDM）患者视觉通路功能异常，但其异常机制尚不清楚。据推测，血糖水平的短期变化会影响IDDM患者的视觉通路功能。
方法
在高胰岛素钳夹期间，使用法恩斯沃思-芒塞尔100色调试验（100色调试验）对10例无并发症的无视网膜病变的IDDM患者进行颜色辨别测量。在血糖稳定正常后，患者分别在至少间隔1周的不同时间，随机依次接受使血糖升高（14 mmol/L）、维持血糖正常（5 mmol/L）和使血糖降低（2.5 mmol/L）的处理。
结果
血糖的短期（1 - 2小时）变化不影响颜色辨别：血糖为2.5 mmol/L时的平均（标准差）100色调误差评分为34（22），血糖为5 mmol/L时为35（33），血糖为14 mmol/L时为39（28）。
结论
这些数据表明，血糖的短期（1 - 2小时）变化不是无视网膜病变的IDDM患者视觉通路功能障碍的机制。
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