无视网膜病变的糖尿病患者中胶原蛋白褐变率的年龄相关性正常化。
Age-related normalization of the browning rate of collagen in diabetic subjects without retinopathy.
作者信息
Monnier V M, Elmets C A, Frank K E, Vishwanath V, Yamashita T
出版信息
J Clin Invest. 1986 Sep;78(3):832-5. doi: 10.1172/JCI112648.
The age-related changes in collagen-linked fluorescence (browning) were investigated in skin from subjects with long-standing type I diabetes. Overall browning rates were 2.4 times higher in diabetics than in controls (P less than 0.02) and slope intercept accurately reflected the mean age of onset of diabetes (11.6 vs. 11.2 yr), suggesting that the browning process has the attributes of a biological clock. Browning rates were not different in controls and diabetics without retinopathy (P greater than 0.05) but were 2.4 (P less than 0.05) and 2.7 (P less than 0.01) times increased in the presence of background and proliferative retinopathy, respectively. Compared with subjects with retinopathy, individual browning rates since onset of diabetes decreased with advancing age in subjects free of retinopathy (P less than 0.001). Extrapolation revealed that they would become identical to that of nondiabetic subjects by the age of 66.4 yr. These results suggest the presence of a mechanism that controls the browning rate of collagen in diabetics who do not develop retinopathy.
对患有长期I型糖尿病的受试者的皮肤中与胶原蛋白相关的荧光（褐变）的年龄相关变化进行了研究。糖尿病患者的总体褐变率比对照组高2.4倍（P<0.02），斜率截距准确反映了糖尿病发病的平均年龄（11.6岁对11.2岁），这表明褐变过程具有生物钟的特征。在没有视网膜病变的对照组和糖尿病患者中，褐变率没有差异（P>0.05），但在有背景性视网膜病变和增殖性视网膜病变的情况下，褐变率分别增加了2.4倍（P<0.05）和2.7倍（P<0.01）。与患有视网膜病变的受试者相比，无视网膜病变的受试者自糖尿病发病以来的个体褐变率随着年龄的增长而降低（P<0.001）。外推显示，到66.4岁时，他们的褐变率将与非糖尿病受试者相同。这些结果表明，在未发生视网膜病变的糖尿病患者中存在一种控制胶原蛋白褐变率的机制。
Zotero 插件