Malamitsi-Puchner A, Minaretzis D, Martzeli L, Papas C
Department of Neonatology, Alexandra University, Athens, Greece.
Gynecol Obstet Invest. 1993;36(1):25-8. doi: 10.1159/000292588.
The purpose of this study is to investigate the relationship of creatine kinase (CK) and its isoenzyme levels in the newborn to the mode of delivery, time interval from birth (divided in four 6-hour time periods), parity and sex of the neonates. During the 1st postpartum day, serum levels of CK and its isoenzymes (CK-MM, CK-MB, CK-BB) were determined from 115 healthy full-term neonates born consecutively either by spontaneous vaginal delivery (VD, n = 85) or by elective cesarean section (CS, n = 30). The multiple regression analysis was applied. Total CK levels were positively correlated with VD (p < 0.0003). This was mainly attributed to a rise in the CK-MM activity which presented a similar pattern to CK. CK-MB activity was also positively correlated with VD. In contrast, CK-BB was negatively correlated to the postpartum time period. Neonatal sex and parity did not influence CK and its isoenzyme levels significantly. In conclusion, VD contributes significantly to an increase in CK levels during the 1st day of extrauterine life.
本研究旨在探讨新生儿肌酸激酶（CK）及其同工酶水平与分娩方式、出生后的时间间隔（分为四个6小时时间段）、新生儿的胎次和性别之间的关系。在产后第1天，对115例连续出生的健康足月新生儿进行了研究，这些新生儿分别通过自然阴道分娩（VD，n = 85）或选择性剖宫产（CS，n = 30）出生，并测定了其血清CK及其同工酶（CK-MM、CK-MB、CK-BB）水平。应用了多元回归分析。总CK水平与VD呈正相关（p < 0.0003）。这主要归因于CK-MM活性的升高，其呈现出与CK相似的模式。CK-MB活性也与VD呈正相关。相反，CK-BB与产后时间段呈负相关。新生儿性别和胎次对CK及其同工酶水平没有显著影响。总之，VD对宫外生活第1天CK水平的升高有显著贡献。
