Brodell R T, Bredle D L
Northeastern Ohio Universities College of Medicine, Rootstown, USA.
Dermatol Surg. 1995 Mar;21(3):213-8. doi: 10.1111/j.1524-4725.1995.tb00155.x.
The treatment of palmar and plantar warts is difficult and often frustrating. The need for multiple destructive treatments and recurrences after apparent cure are common.
The purpose of this study was to determine if intralesional natural alpha interferon might offer an effective alternative therapy for common plantar and palmar warts.
A series of 22 private office patients with palmar and plantar warts were treated with intralesional natural alpha interferon using a needless injector. We treated twice weekly for a minimum of 8 weeks or until clear.
Sixteen patients (73%) showed complete clearing of their warts in a mean of 11 weeks of twice weekly treatment. Upon follow-up, which averaged 9.5 months, 17 of 21 patients (81%) remained clear of their warts.
Natural alpha interferon by needless injector appears to represent an effective alternative treatment for palmar and plantar human papillomavirus lesions. Further study of this modality is indicated.
掌跖疣的治疗困难且常常令人沮丧。需要多次破坏性治疗且在看似治愈后复发的情况很常见。
本研究的目的是确定病灶内注射天然α干扰素是否可为常见的掌跖疣提供一种有效的替代疗法。
使用无针注射器对一系列22例患有掌跖疣的私人诊所患者进行病灶内天然α干扰素治疗。我们每周治疗两次，最少治疗8周或直至疣体清除。
16例患者（73%）在每周两次的平均11周治疗后疣体完全清除。随访平均9.5个月时，21例患者中的17例（81%）疣体仍未复发。
通过无针注射器注射天然α干扰素似乎是掌跖人乳头瘤病毒病变的一种有效替代治疗方法。有必要对这种治疗方式做进一步研究。
