Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.
J Korean Med Sci. 2009 Oct;24(5):889-93. doi: 10.3346/jkms.2009.24.5.889. Epub 2009 Sep 23.
Various treatment methods have been adopted in the management of warts; however, there is still no consensus on first-line treatment. This study was designed to evaluate the efficacy of long-pulsed Nd:YAG laser in the treatment of warts. Over the course of 1 yr, 369 patients with recalcitrant or untreated warts were exposed to a long-pulsed Nd:YAG laser. The following parameters were used: spot size, 5 mm; pulse duration, 20 msec; and fluence, 200 J/cm(2). No concomitant topical treatment was used. In all, 21 patients were lost during follow up; hence, the data for 348 patients were evaluated. The clearance rate was 96% (336 of the 348 treated warts were eradicated). The clearance rate of verruca vulgaris after the first treatment was very high (72.6%), whereas the clearance rate of deep palmopantar warts after the first treatment was low (44.1%). During a median follow-up period of 2.24 months (range, 2-10 months), 11 relapses were seen (recurrence rate, 3.27%). In conclusion, long-pulsed Nd:YAG laser is safe and effective for the removal or reduction of warts and is less dependent on patient compliance than are other treatment options.
各种治疗方法已被用于疣的治疗管理中；然而，对于一线治疗方案仍没有达成共识。本研究旨在评估长脉冲 Nd:YAG 激光治疗疣的疗效。在 1 年的时间里，369 例难治性或未经治疗的疣患者接受了长脉冲 Nd:YAG 激光治疗。使用的参数如下：光斑大小为 5mm；脉冲持续时间为 20msec；能量密度为 200J/cm²。未同时使用局部治疗。在随访过程中，有 21 例患者失访；因此，对 348 例患者的数据进行了评估。清除率为 96%（336 例治疗的疣被清除）。初次治疗后寻常疣的清除率非常高（72.6%），而初次治疗后手掌足底深部疣的清除率较低（44.1%）。在中位随访期 2.24 个月（范围为 2-10 个月）期间，有 11 例复发（复发率为 3.27%）。总之，长脉冲 Nd:YAG 激光对于去除或减少疣是安全有效的，并且比其他治疗方法更不依赖于患者的依从性。
