Younes M, Katikaneni P R, Lechago J
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
Histopathology. 1995 Jan;26(1):33-7. doi: 10.1111/j.1365-2559.1995.tb00617.x.
Mucosal hyperplasia of the appendix is a seemingly benign change of poorly understood significance, at times found in patients with colorectal malignancy. To determine the incidence of this change and its association with colonic adenocarcinoma, we have examined the appendiceal mucosa in 122 ileocolectomy specimens gathered between 1987 and 1990, and in 273 consecutive appendectomies carried out during 1990 at The Methodist Hospital in Houston, Texas. We found that 23 out of 122 ileocolectomies (18.8%) showed mucosal hyperplasia of the appendix and, of these, 17 (77%) were associated with colorectal malignancy, predominantly of the right side. Moreover, 24 of 273 appendectomies (8.8%) exhibited the presence of mucosal hyperplasia and, of these, six (25%) also were associated with adenocarcinoma of the colon. On the basis of this significant rate of association, we feel that a concomitant colorectal carcinoma should be ruled out in patients who exhibit mucosal hyperplasia of the appendix.
阑尾黏膜增生是一种意义尚不清楚的看似良性的改变，有时在结直肠癌患者中发现。为了确定这种改变的发生率及其与结肠腺癌的关联，我们检查了1987年至1990年间收集的122例回肠结肠切除术标本以及1990年在得克萨斯州休斯顿卫理公会医院连续进行的273例阑尾切除术中的阑尾黏膜。我们发现，122例回肠结肠切除术中23例（18.8%）显示阑尾黏膜增生，其中17例（77%）与结直肠癌相关，主要是右侧。此外，273例阑尾切除术中24例（8.8%）存在黏膜增生，其中6例（25%）也与结肠癌相关。基于这种显著的关联率，我们认为对于表现出阑尾黏膜增生的患者，应排除同时存在的结直肠癌。
