Calles-Escandón J, Arciero P J, Gardner A W, Bauman C, Poehlman E T
Division of Endocrinology, Metabolism, and Nutrition, University of Vermont, Burlington 05405.
J Appl Physiol (1985). 1995 Jan;78(1):266-71. doi: 10.1152/jappl.1995.78.1.266.
The present study tested the hypothesis that a decrease in basal fat oxidation in aging women is related to a loss of fat-free mass. Thirty-two nonsmoking women with a wide range of age (18-73 yr) were characterized for body composition (underwater weight), maximal aerobic capacity, and basal fat oxidation (indirect calorimetry). Results showed that fat oxidation was negatively correlated with age (r2 = 0.17, P = 0.017) but was positively correlated with the fat-free mass (r2 = 0.48, P < 0.0001) and with the level of aerobic fitness (maximal aerobic capacity) (r2 = 0.22, P = 0.007). Unexpectedly, fat oxidation had no relationship with fat mass (r2 = 0.07, P = 0.136). Partial correlation analysis showed that the decline in fat-free mass, and not the age or maximal O2 consumption, was the best single predictor of the decline in basal fat oxidation. These results support the theory that a decrease in fat oxidation with advancing age in healthy women is associated with a decrease in the fat-free mass and not age per se. Interventions that increase or preserve the quantity of fat-free mass (e.g., exercise training) may enhance fat oxidation and thus lessen the age-associated adiposity in women.
本研究检验了这样一个假设，即老年女性基础脂肪氧化的减少与去脂体重的减少有关。三十二名年龄范围较广（18 - 73岁）的非吸烟女性，对其身体成分（水下称重法）、最大有氧能力和基础脂肪氧化（间接量热法）进行了测定。结果显示，脂肪氧化与年龄呈负相关（r2 = 0.17，P = 0.017），但与去脂体重呈正相关（r2 = 0.48，P < 0.0001），也与有氧适能水平（最大有氧能力）呈正相关（r2 = 0.22，P = 0.007）。出乎意料的是，脂肪氧化与脂肪量无关（r2 = 0.07，P = 0.136）。偏相关分析表明，去脂体重的下降，而非年龄或最大摄氧量，是基础脂肪氧化下降的最佳单一预测指标。这些结果支持了这样一种理论，即健康女性随着年龄增长脂肪氧化的减少与去脂体重的减少有关，而非年龄本身。增加或保持去脂体重的干预措施（如运动训练）可能会增强脂肪氧化，从而减轻女性与年龄相关的肥胖。
