Stobo J D, Loehnen C P
Mayo Clin Proc. 1976 Aug;51(8):479-83.
The immunologic responses, both cell-mediated and humoral, to exogenous antigens reflect a crucial balance between extrinsic forces which can either augment or suppress the reactivity of T and B effector cells. It is probable that similar immunoregulatory influences play a key role in maintaining tolerance to some self-antigens. Thus, despite the presence of cells potentially capable of reacting to autologous antigens, lack of autoimmunity might reflect either an absence of amplifying or a preponderance of suppressive immunoregulatory forces. Within this framework, data obtained indicating aberrances of immunoregulation in patients with systemic lupus erythematosus are discussed, specifically as the aberrances may be causally related to the autoimmune nature of this disease.
针对外源性抗原的免疫反应，包括细胞介导的和体液介导的反应，反映了外在因素之间的关键平衡，这些外在因素既可以增强也可以抑制T和B效应细胞的反应性。类似的免疫调节影响可能在维持对某些自身抗原的耐受性方面发挥关键作用。因此，尽管存在潜在能够对自身抗原作出反应的细胞，但缺乏自身免疫可能反映出缺乏放大性免疫调节力或抑制性免疫调节力占优势。在此框架内，讨论了系统性红斑狼疮患者免疫调节异常的数据，特别是这些异常可能与该疾病的自身免疫性质存在因果关系。
