系统性红斑狼疮患者体内的一种免疫调节血清抑制剂。
A serum inhibitor of immune regulation in patients with systemic lupus erythematosus.
作者信息
Twomey J J, Laughter A H, Steinberg A D
出版信息
J Clin Invest. 1978 Sep;62(3):713-5. doi: 10.1172/JCI109180.
Abstract
Normal mononuclear leukocytes were incubated with serum from patients with active systemic lupus erythematosus (SLE) and healthy subjects and then studied on lymphoproliferative tests. Serum from SLE patients that contained an autoantibody to a subpopulation of thymus-derived (T) lymphocytes inhibited suppressor T-cell activity induced with concanavalin A. These sera did not inhibit lymphoproliferative responses or suppression by monocytoid cells. Mitogen-activated suppressor cells were not inhibited with serum from SLE patients or healthy subjects lacking T-cell autoantibody. This abnormality may contribute to the altered immune response that occurs with SLE.
摘要
将正常单核白细胞与活动性系统性红斑狼疮（SLE）患者及健康受试者的血清一起孵育，然后进行淋巴细胞增殖试验研究。SLE患者血清中含有针对胸腺来源（T）淋巴细胞亚群的自身抗体，该血清可抑制伴刀豆球蛋白A诱导的抑制性T细胞活性。这些血清不会抑制单核样细胞的淋巴细胞增殖反应或抑制作用。对于缺乏T细胞自身抗体的SLE患者或健康受试者的血清，丝裂原激活的抑制细胞不会受到抑制。这种异常可能导致SLE患者出现免疫反应改变。
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