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检测进行性多灶性白质脑病患者脑脊液中 JC 病毒 DNA 的诊断价值。

Diagnostic value of detecting JC virus DNA in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.

作者信息

Fong I W, Britton C B, Luinstra K E, Toma E, Mahony J B

机构信息

Department of Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada.

出版信息

J Clin Microbiol. 1995 Feb;33(2):484-6. doi: 10.1128/jcm.33.2.484-486.1995.

DOI:10.1128/jcm.33.2.484-486.1995
PMID:7714213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC227972/
Abstract

JC virus DNA was detected by PCR in the cerebrospinal fluid of 17 of 23 (73.9%) patients with confirmed cases of progressive multifocal leukoencephalopathy and 2 of 48 (4.2%) controls without progressive multifocal leukoencephalopathy. The sensitivity and specificity of this PCR were 74 and 95.8%, respectively, while the positive and negative predictive values were 89.5 and 88.5%, respectively.

摘要

在23例确诊为进行性多灶性白质脑病的患者中，有17例（73.9%）的脑脊液通过聚合酶链反应（PCR）检测到JC病毒DNA；在48例无进行性多灶性白质脑病的对照者中，有2例（4.2%）检测到该病毒DNA。此PCR检测的敏感性和特异性分别为74%和95.8%，阳性预测值和阴性预测值分别为89.5%和88.5%。

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