Martinez-Piñeiro L, Lopez-Tello J, Alonso Dorrego J M, Cisneros J, Cuervo E, Martinez-Piñeiro J A
Service of Urology, La Paz Hospital, Autonomous University of Madrid, Spain.
J Urol. 1995 May;153(5):1487-90.
We compared the effect of intracavernous administration of sodium nitroprusside, a nitric oxide donor and, therefore, stimulator of the cyclic guanosine monophosphate pathway, with the activity of prostaglandin E1, which is a stimulator of the cyclic adenosine monophosphate pathway. To date 105 patients with erectile dysfunction have entered the study. As part of the diagnostic evaluation every patient received an intracavernous injection of 20 micrograms prostaglandin E1 and a second injection of sodium nitroprusside at different concentrations (100 micrograms in 10 patients, 300 micrograms in 60 and 400 micrograms in 35). Sodium nitroprusside at a dose of 100 micrograms was not effective for inducing erections. Prostaglandin E1 induced better responses overall than sodium nitroprusside at 300 and 400 micrograms (p < 0.001). The overall duration of erections was also significantly longer with prostaglandin E1 (mean 88.5 minutes) than with 300 micrograms sodium nitroprusside (mean 50.8 minutes, p < 0.001) but did not reach statistical significance compared to 400 micrograms sodium nitroprusside (mean 42.2 minutes). Side effects were minimal with both drugs. Although sodium nitroprusside has several benefits over prostaglandin E1 for intracavernous use (such as lower cost, absence of local pain and shorter action, allowing detumescence after orgasm and decreasing the risk of priapism), prostaglandin E1 still remains the agent of choice for intracavernous use.
我们比较了海绵体内注射硝普钠（一种一氧化氮供体，因此也是环磷酸鸟苷途径的刺激剂）与前列腺素E1（一种环磷酸腺苷途径的刺激剂）的作用。迄今为止，已有105例勃起功能障碍患者进入该研究。作为诊断评估的一部分，每位患者均接受了海绵体内注射20微克前列腺素E1，并在不同浓度下（10例患者注射100微克，60例患者注射300微克，35例患者注射400微克）第二次注射硝普钠。100微克剂量的硝普钠对诱导勃起无效。总体而言，前列腺素E1比300微克和400微克的硝普钠诱导的反应更好（p<0.001）。前列腺素E1诱导勃起的总持续时间（平均88.5分钟）也明显长于300微克硝普钠（平均50.8分钟，p<0.001），但与400微克硝普钠（平均42.2分钟）相比未达到统计学显著性。两种药物的副作用都很小。尽管硝普钠在海绵体内使用方面比前列腺素E1有几个优点（如成本较低、无局部疼痛且作用时间较短，可在射精后消肿并降低阴茎异常勃起的风险），但前列腺素E1仍然是海绵体内使用的首选药物。
