Schramek P, Plas E G, Hübner W A, Pflüger H
Department of Urology, Krankenhaus Lainz, Vienna, Austria.
J Urol. 1994 Oct;152(4):1108-10. doi: 10.1016/s0022-5347(17)32515-6.
Despite the availability of prostaglandin E1 for more than 7 years as a diagnostic and therapeutic tool in patients with erectile dysfunction, the problem of penile discomfort after prostaglandin E1 application has remained unsolved. In a randomized, double-blind, crossover study we investigated the effect of 2 different prostaglandin E1-procaine concentrations on 24 patients suffering from pain following intracorporeal injection of prostaglandin E1 alone. Intracavernous injection of 20 micrograms. prostaglandin E1 with 10 mg. procaine (study 1) failed to improve local painful sensations. The combination of 20 micrograms. prostaglandin E1 with 20 mg. procaine (study 2) decreased the incidence of local pain significantly (p < 0.01). These preliminary results show that the combination of prostaglandin E1 plus procaine represents a beneficial alternative in patients with penile pain due to the single substance.
尽管前列腺素E1作为勃起功能障碍患者的诊断和治疗工具已有7年多的时间，但应用前列腺素E1后阴茎不适的问题仍未得到解决。在一项随机、双盲、交叉研究中，我们调查了2种不同浓度的前列腺素E1-普鲁卡因对24例单独海绵体内注射前列腺素E1后疼痛患者的影响。海绵体内注射20微克前列腺素E1加10毫克普鲁卡因（研究1）未能改善局部疼痛感觉。20微克前列腺素E1与20毫克普鲁卡因联合使用（研究2）显著降低了局部疼痛的发生率（p<0.01）。这些初步结果表明，对于因单一物质导致阴茎疼痛的患者，前列腺素E1加普鲁卡因联合使用是一种有益的替代方法。
