Culić M, Saponjić J, Janković B, Rakić L
Institute for Biological Research, Belgrade, Yugoslavia.
Neurosci Lett. 1994 Dec 5;182(2):259-62. doi: 10.1016/0304-3940(94)90811-7.
The modulation of cerebellar Purkinje cell activity and EEG from parietal cortex was studied in the rat model of epilepsy induced by penicillin under acute haloperidol and amphetamine treatment. The discharge pattern of Purkinje cells showed tendency towards inhibition and EEG power spectra increased after parenteral administration of penicillin (1000000 IU/kg, i.p.). Acute haloperidol treatment (1 mg/kg, i.p.), performed after the development of penicillin induced epileptic episodes, elicited a prominent excitation of Purkinje cell discharges associated with parallel increase in mean EEG power spectra. However, acute DL-amphetamine treatment induced marked suppression of Purkinje cell discharges as well as outstanding decrease of the mean EEG power spectra. These results indicate that cerebellar Purkinje cells may be important in the control of seizure activity and that noradrenergic influences are relevant.
在急性氟哌啶醇和苯丙胺治疗下，利用青霉素诱导的大鼠癫痫模型，研究了小脑浦肯野细胞活动和顶叶皮质脑电图的调制。静脉注射青霉素（1000000 IU/kg，腹腔注射）后，浦肯野细胞的放电模式呈抑制趋势，脑电图功率谱增加。在青霉素诱导的癫痫发作出现后进行急性氟哌啶醇治疗（1 mg/kg，腹腔注射），可引起浦肯野细胞放电的显著兴奋，同时平均脑电图功率谱平行增加。然而，急性DL-苯丙胺治疗可显著抑制浦肯野细胞放电，并使平均脑电图功率谱显著降低。这些结果表明，小脑浦肯野细胞可能在癫痫活动的控制中起重要作用，且去甲肾上腺素能影响与之相关。
