甲基胆蒽诱导的小鼠肉瘤的H-2抗原测定及免疫原性
Measurement of H-2 antigen and immunogenicity of methylcholanthrene-induced murine sarcomas.
作者信息
Pearson T, Sikora K, Lennox E
出版信息
Br J Cancer. 1978 Apr;37(4):530-5. doi: 10.1038/bjc.1978.81.
Abstract
For each of a set of 11 methylcholanthrene-induced sarcomas of B10 mice, we measured the amount of H-2 antigen by absorption of a specific antiserum, and the strength of the tumour-specific transplantation antigen by a transplantation assay, to see whether they are correlated. No obvious correlation was seen. We showed that cell suspensions of tumours taken directly from the animal are contaminated by host cells which make a substantial contribution in H-2 assays. Since this contamination was lost after several passages in vitro, the amount of H-2 on tumour cells was assayed only after such passages.
摘要
对于一组11个甲基胆蒽诱导的B10小鼠肉瘤，我们通过特异性抗血清的吸收来测量H-2抗原的量，并通过移植试验来测量肿瘤特异性移植抗原的强度，以观察它们是否相关。未发现明显的相关性。我们发现，直接从动物身上获取的肿瘤细胞悬液被宿主细胞污染，这些宿主细胞在H-2检测中起了很大作用。由于这种污染在体外传代几次后就消失了，因此仅在传代后才检测肿瘤细胞上的H-2量。
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