Levin J O, Rhén M, Sikström E
National Institute of Occupational Health, Research Department in Umeå, Sweden.
Sci Total Environ. 1995 Feb 24;163(1-3):169-77. doi: 10.1016/0048-9697(95)04488-m.
Polycyclic aromatic hydrocarbon (PAH) levels in air, and worker urinary 1-hydroxypyrene levels were studied in a coke oven, a Söderberg aluminium smelter pot-room, and during road-paving. Increased PAH exposure was shown to cause increased 1-hydroxypyrene excretion. Road-paving gave low PAH exposure, but resulted in a detectable elevated urinary 1-hydroxypyrene level. Background urinary 1-hydroxypyrene levels in office workers were determined, and a statistically significant difference between smokers and non-smokers was observed. It is suggested that urinary 1-hydroxypyrene can be used as biological exposure index for PAH exposure.
对焦炭厂、 Söderberg 铝冶炼车间以及铺路过程中的空气中多环芳烃（PAH）水平和工人尿中1-羟基芘水平进行了研究。结果表明，PAH暴露增加会导致1-羟基芘排泄增加。铺路过程中PAH暴露水平较低，但尿中1-羟基芘水平仍可检测到升高。测定了办公室工作人员尿中1-羟基芘的背景水平，观察到吸烟者和非吸烟者之间存在统计学上的显著差异。建议尿中1-羟基芘可作为PAH暴露的生物暴露指标。
