VanRooij J G, Bodelier-Bade M M, Hopmans P M, Jongeneelen F J
Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands.
Ann Occup Hyg. 1994 Jun;38(3):247-56. doi: 10.1093/annhyg/38.3.247-a.
The effect of hygienic skin protective measures on the internal exposure to polycyclic aromatic hydrocarbons (PAHs) was studied in 13 coke-oven workers. The study took place over 2 consecutive weeks. In 1 week the subjects worked under the normal circumstances, in the other week extra hygienic skin protective measures were instituted: laundered working clothes and a new pair of gloves before each 8-h work shift, and the washing both of the hands and of the face before each break. Biological monitoring was undertaken to measure the effect of the extra hygienic measures on the urinary 1-hydroxypyrene excretion, which is a measure of the internal PAH exposure. The increase of the urinary 1-hydroxypyrene concentration over the 4-day workweek was on average 37% lower when extra hygienic measures were taken, being 1.3 instead of 2.3 mumole 1-hydroxypyrene per mole creatinine (P = 0.03, N = 13). This study demonstrates that simple hygienic skin protective measures result in a significant reduction of the internal PAH exposure.
在13名炼焦炉工人中研究了皮肤卫生防护措施对多环芳烃（PAHs）体内暴露的影响。该研究持续了连续2周。在其中1周，受试者在正常情况下工作，在另一周采取了额外的皮肤卫生防护措施：每次8小时工作班次前更换清洗过的工作服和一副新手套，每次休息前洗手和洗脸。进行了生物监测，以测量额外卫生措施对尿中1-羟基芘排泄的影响，尿中1-羟基芘排泄是PAHs体内暴露的一个指标。采取额外卫生措施时，4天工作周期间尿中1-羟基芘浓度的平均增幅比未采取措施时低37%，分别为每摩尔肌酐1.3微摩尔1-羟基芘和2.3微摩尔1-羟基芘（P = 0.03，N = 13）。本研究表明，简单的皮肤卫生防护措施可显著降低PAHs的体内暴露。
