Cosman D
Department of Molecular Biology, Immunex Research and Development Corporation, Seattle, WA 98101.
Cytokine. 1993 Mar;5(2):95-106. doi: 10.1016/1043-4666(93)90047-9.
The receptors for a number of cytokines show amino acid sequence homologies in their extracellular domains that define a new family of molecules, the hematopoietin receptors. This review focuses on some recent significant developments in our understanding of the structure and function of these receptors. These include the first X-ray crystallographic determination of the structure of a ligand-receptor complex for one of these family members, the subunit composition of some of the more complex multimeric receptors, the involvement of certain subunits in the receptors for more than one cytokine, and aspects of signal transduction.
许多细胞因子的受体在其细胞外结构域显示出氨基酸序列同源性，这些同源性定义了一个新的分子家族——造血因子受体。本综述重点关注我们对这些受体的结构和功能理解方面的一些近期重大进展。这些进展包括首次通过X射线晶体学确定这些家族成员之一的配体 - 受体复合物的结构、一些更复杂的多聚体受体的亚基组成、某些亚基在不止一种细胞因子受体中的参与情况以及信号转导方面。
