在一名急性嗜酸性粒细胞性肺炎患者的支气管肺泡灌洗液和外周血中，白细胞介素-5占主导。

IL-5 predominant in bronchoalveolar lavage fluid and peripheral blood in a patient with acute eosinophilic pneumonia.

作者信息

Yamaguchi S, Okubo Y, Hossain M, Fujimoto K, Honda T, Kubo K, Sekiguchi M, Takatsu K

机构信息

First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto.

出版信息

Intern Med. 1995 Jan;34(1):65-8. doi: 10.2169/internalmedicine.34.65.

DOI:10.2169/internalmedicine.34.65

PMID:7718986

Abstract

We describe an acute eosinophilic pneumonia (AEP) patient with bronchoalveolar lavage fluid (BALF). Eosinophil cell number (47%), content of interleukin (IL)-5 (8.22 x 10(2) pg/ml) and eosinophil cationic protein (9.25 micrograms/ml) were high in BALF. No eosinophilia was seen in peripheral blood on admission; however, content of IL-5 was 9.47 x 10(2) pg/ml. After methylprednisolone pulse therapy, he improved rapidly with a reduction in eosinophil cell number (7%) and the content of IL-5 (< 100 pg/ml) in BALF. However, a high content of IL-5 (6.9 x 10(2) pg/ml) and transient eosinophilia (17.5%) were seen in peripheral blood. It is important to distinguish between AEP and infectious pneumonia, because of the differing treatments. If the diagnosis of AEP is doubtful, BALF should be performed early.

摘要

我们描述了一名患有支气管肺泡灌洗（BALF）的急性嗜酸性粒细胞性肺炎（AEP）患者。BALF中嗜酸性粒细胞数量（47%）、白细胞介素（IL）-5含量（8.22×10² pg/ml）和嗜酸性粒细胞阳离子蛋白（9.25 μg/ml）均较高。入院时外周血未见嗜酸性粒细胞增多；然而，IL-5含量为9.47×10² pg/ml。甲泼尼龙冲击治疗后，患者迅速好转，BALF中嗜酸性粒细胞数量减少（7%），IL-5含量降低（<100 pg/ml）。然而，外周血中出现了高含量的IL-5（6.9×10² pg/ml）和短暂性嗜酸性粒细胞增多（17.5%）。由于治疗方法不同，区分AEP和感染性肺炎很重要。如果AEP的诊断存疑，应尽早进行BALF检查。