Okubo Y, Horie S, Hachiya T, Momose T, Tsukadaira A, Takashi S, Suzuki J, Isobe M, Sekiguchi M
First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan.
Int Arch Allergy Immunol. 1998 May;116(1):76-80. doi: 10.1159/000023928.
Acute eosinophilic pneumonia (AEP) is a rare disease with unknown etiology. To examine pathophysiology of AEP we measured the cell number of eosinophils and eosinophil active cytokines in the peripheral blood and bronchoalveolar lavage fluid (BALF) of AEP patients and compared the levels with those measured in chronic eosinophilic pneumonia (CEP) patients.
Cell number of eosinophils in peripheral blood and BALF from patients with AEP (n = 3) and CEP (n = 3) were measured. Eosinophil active cytokines in serum and BALF from the patients were measured using ELISA.
Eosinophil cell number in peripheral blood was 274-1,377/mm3 in AEP and 526-2,500/mm3 in CEP. The percentages of BALF eosinophils were high in AEP and CEP. Eosinophilia disappeared after methylprednisolone pulse therapy (1 g for 3 days) in AEP, however the cell number of eosinophils gradually increased after methylprednisolone pulse therapy and then spontaneously decreased to within normal range without any further medication. The concentrations of IL-5 in AEP were very high in serum and in BALF, however the concentrations in CEP were low in serum and BALF.
AEP is a disease in which eosinophil active cytokine IL-5 is predominantly involved; CEP is not. The factors involving eosinophil infiltration to inflammatory loci differ between AEP and CEP.
急性嗜酸性粒细胞性肺炎（AEP）是一种病因不明的罕见疾病。为了研究AEP的病理生理学，我们测量了AEP患者外周血和支气管肺泡灌洗液（BALF）中嗜酸性粒细胞的细胞数量以及嗜酸性粒细胞活性细胞因子，并将这些水平与慢性嗜酸性粒细胞性肺炎（CEP）患者中测量的水平进行比较。
测量了AEP患者（n = 3）和CEP患者（n = 3）外周血和BALF中嗜酸性粒细胞的细胞数量。使用酶联免疫吸附测定法（ELISA）测量患者血清和BALF中的嗜酸性粒细胞活性细胞因子。
AEP患者外周血中嗜酸性粒细胞数量为274 - 1377/mm³，CEP患者为526 - 2500/mm³。AEP和CEP患者BALF中嗜酸性粒细胞百分比均较高。AEP患者经甲泼尼龙冲击治疗（1g，连续3天）后嗜酸性粒细胞增多症消失，但甲泼尼龙冲击治疗后嗜酸性粒细胞数量逐渐增加，然后在未使用任何进一步药物的情况下自发降至正常范围内。AEP患者血清和BALF中白细胞介素-5（IL-5）浓度非常高，而CEP患者血清和BALF中IL-5浓度较低。
AEP是一种主要涉及嗜酸性粒细胞活性细胞因子IL-5的疾病；CEP则不然。AEP和CEP中嗜酸性粒细胞浸润到炎症部位的相关因素不同。
