Kawanishi M, Fukuda S, Kawaguchi H, Kohmoto K, Haruma K, Kajiyama G
Okamoto Hospital, Hiroshima, Japan.
J Gastroenterol. 1995 Feb;30(1):16-20. doi: 10.1007/BF01211369.
Helicobacter pylori in the stomach is an etiological factor of gastritis and peptic ulcer. It is now considered that gastric cancer can be, at least in some cases, a late complication of H. pylori infection. In 123 consecutive endoscopic antral biopsies obtained from patients with the Okamoto Hospital, the specimens were subjected to the rapid urease test (RUT), histology (H&E stain), and culture, for the identification of H. pylori. The results of these methods were compared semi-quantitatively in order to evaluate these detection methods for identifying H. pylori. The results of these methods were found to agree well, with the Spearman's rank correlation coefficient between RUT and culture being 0.90 (P < 0.01) and that between histology and culture being 0.80 (P < 0.01). RUT is considered to be a very simple, sensitive, and highly specific test which enables the endoscopist to diagnose H. pylori infection.
胃内的幽门螺杆菌是胃炎和消化性溃疡的病因。现在认为，至少在某些情况下，胃癌可能是幽门螺杆菌感染的晚期并发症。在从冈本医院患者中连续获取的123份内镜下胃窦活检标本中，对标本进行快速尿素酶试验（RUT）、组织学检查（苏木精-伊红染色）和培养，以鉴定幽门螺杆菌。对这些方法的结果进行半定量比较，以评估这些检测幽门螺杆菌的方法。发现这些方法的结果吻合良好，RUT与培养之间的Spearman等级相关系数为0.90（P<0.01），组织学与培养之间的相关系数为0.80（P<0.01）。RUT被认为是一种非常简单、灵敏且高度特异的检测方法，可使内镜医师诊断幽门螺杆菌感染。
