非溃疡性消化不良患者对幽门弯曲菌的全身及局部抗体反应
Systemic and local antibody responses to gastric Campylobacter pyloridis in non-ulcer dyspepsia.
作者信息
Rathbone B J, Wyatt J I, Worsley B W, Shires S E, Trejdosiewicz L K, Heatley R V, Losowsky M S
出版信息
Gut. 1986 Jun;27(6):642-7. doi: 10.1136/gut.27.6.642.
Abstract
Antibody titres to Campylobacter pyloridis in serum and gastric juice were estimated by an enzyme linked immunosorbent assay (ELISA) to whole organisms obtained from bacterial culture in 39 patients with non-ulcer dyspepsia. Whereas 20 of the 21 patients with chronic gastritis had gastric C pyloridis, 17 patients with no C pyloridis had normal histology in the gastric antrum and body. Significantly raised serum IgG and IgA antibody titres to C pyloridis were found in colonised patients with gastritis. Patients with raised IgG antibody to C pyloridis were also shown to have significantly raised titres to other Campylobacter species, suggesting antigenic cross reactivity. Gastric juice antibodies were also studied and IgA titres to C pyloridis were detected in a proportion of patients with gastritis, together with low levels of IgM, but no IgG.
摘要
采用酶联免疫吸附测定（ELISA）法，对39例非溃疡性消化不良患者细菌培养获得的全菌进行检测，以评估血清和胃液中幽门弯曲菌的抗体滴度。21例慢性胃炎患者中有20例胃内存在幽门弯曲菌，17例无幽门弯曲菌的患者胃窦和胃体组织学正常。在患有胃炎且细菌定植的患者中，发现血清中针对幽门弯曲菌的IgG和IgA抗体滴度显著升高。对幽门弯曲菌IgG抗体升高的患者研究还发现，其针对其他弯曲菌属的抗体滴度也显著升高，提示存在抗原交叉反应。同时对胃液抗体进行了研究，部分胃炎患者检测到针对幽门弯曲菌的IgA滴度，同时伴有低水平的IgM，但未检测到IgG。
相似文献
1
Systemic and local antibody responses to gastric Campylobacter pyloridis in non-ulcer dyspepsia.非溃疡性消化不良患者对幽门弯曲菌的全身及局部抗体反应
Gut. 1986 Jun;27(6):642-7. doi: 10.1136/gut.27.6.642.
2
Clinical importance of Campylobacter pyloridis and associated serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy.幽门弯曲菌在上消化道内镜检查患者中的临床重要性及相关血清IgG和IgA抗体反应
J Clin Pathol. 1986 Feb;39(2):215-9. doi: 10.1136/jcp.39.2.215.
3
Local immune response to gastric Campylobacter in non-ulcer dyspepsia.非溃疡性消化不良患者对胃弯曲菌的局部免疫反应。
J Clin Pathol. 1986 Aug;39(8):863-70. doi: 10.1136/jcp.39.8.863.
4
Frequency of occurrence of Campylobacter pylori and analysis of the systemic and local immune response.幽门螺杆菌的发生率及全身和局部免疫反应分析
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Oct;266(3-4):526-42. doi: 10.1016/s0176-6724(87)80235-3.
5
Enzyme-linked immunosorbent assay for Campylobacter pyloridis: correlation with presence of C. pyloridis in the gastric mucosa.幽门弯曲菌的酶联免疫吸附测定：与胃黏膜中幽门弯曲菌存在情况的相关性
J Infect Dis. 1987 Mar;155(3):488-94. doi: 10.1093/infdis/155.3.488.
6
Antibodies to Campylobacter pylori in patients with idiopathic dyspepsia.特发性消化不良患者中幽门螺杆菌抗体
Microbiologica. 1989 Jul;12(3):181-8.
7
Campylobacter pylori: clinical, histological, and serological studies.幽门螺杆菌：临床、组织学及血清学研究。
J Clin Pathol. 1988 Dec;41(12):1316-21. doi: 10.1136/jcp.41.12.1316.
8
Diagnostic value of an immunoassay to detect anti Campylobacter pylori antibodies in non-ulcer dyspepsia.一种免疫测定法检测非溃疡性消化不良患者抗幽门螺杆菌抗体的诊断价值
Lancet. 1989 May 27;1(8648):1182-5. doi: 10.1016/s0140-6736(89)92761-x.
9
Evaluation of three Campylobacter pylori antigen preparations for screening sera from patients undergoing endoscopy.评估三种幽门螺杆菌抗原制剂用于筛查接受内镜检查患者的血清。
J Clin Pathol. 1989 Jul;42(7):723-6. doi: 10.1136/jcp.42.7.723.
10
Seroepidemiology of Campylobacter pyloridis.幽门弯曲菌血清流行病学
N Z Med J. 1986 Sep 10;99(809):657-9.
引用本文的文献
1
chronic gastritis updated Sydney grading in relation to endoscopic findings and IgG antibody: diagnostic methods.慢性胃炎悉尼分级与内镜检查结果及IgG抗体的关系：诊断方法
J Microsc Ultrastruct. 2016 Oct-Dec;4(4):167-174. doi: 10.1016/j.jmau.2016.03.004. Epub 2016 Mar 24.
2
Diagnosis of Using Invasive and Noninvasive Approaches.使用侵入性和非侵入性方法进行诊断。 （你提供的原文表述不太完整准确，推测完整内容可能是“Diagnosis of [某种疾病或情况] Using Invasive and Noninvasive Approaches” ）
J Pathog. 2018 May 22;2018:9064952. doi: 10.1155/2018/9064952. eCollection 2018.
3
Population screening and treatment of Helicobacter pylori infection.人群筛查及幽门螺杆菌感染的治疗。
Nat Rev Gastroenterol Hepatol. 2017 Apr;14(4):230-240. doi: 10.1038/nrgastro.2016.195. Epub 2017 Jan 5.
4
Performance evaluation of a rapid whole-blood immunoassay for the detection of IgG antibodies against Helicobacter pylori in daily clinical practice.一种用于在日常临床实践中检测抗幽门螺杆菌IgG抗体的快速全血免疫测定法的性能评估。
Ann Clin Microbiol Antimicrob. 2016 Aug 8;15(1):47. doi: 10.1186/s12941-016-0161-1.
5
Helicobacter pylori vaccination: is there a path to protection?幽门螺杆菌疫苗接种：是否存在保护之路？
World J Gastroenterol. 2014 Sep 14;20(34):11939-49. doi: 10.3748/wjg.v20.i34.11939.
6
7
Mucosal IgA & IL-1β in Helicobacter pylori Infection.幽门螺杆菌感染中的黏膜IgA与白细胞介素-1β
Indian J Clin Biochem. 2013 Jan;28(1):19-23. doi: 10.1007/s12291-012-0262-3. Epub 2012 Sep 26.
8
Increasing gastric juice pH level prior to anti-Helicobacter pylori therapy may be beneficial to the healing of duodenal ulcers.在抗幽门螺杆菌治疗前提高胃液pH值可能有利于十二指肠溃疡的愈合。
Exp Ther Med. 2013 Mar;5(3):912-916. doi: 10.3892/etm.2013.880. Epub 2013 Jan 2.
9
Helicobacter pylori and gastric cancer: factors that modulate disease risk.幽门螺杆菌和胃癌：调节疾病风险的因素。
Clin Microbiol Rev. 2010 Oct;23(4):713-39. doi: 10.1128/CMR.00011-10.
10
Evaluation of rapid urine test for the detection of Helicobacter pylori infection in the Vietnamese population.评估快速尿液检测在越南人群中检测幽门螺杆菌感染的应用。
Dig Dis Sci. 2010 Jan;55(1):89-93. doi: 10.1007/s10620-009-0720-9. Epub 2009 Feb 25.
本文引用的文献
1
Immunoperoxidase study of the secretory immunoglobulin system and lysozyme in normal and diseased gastric mucosa.正常和病变胃黏膜中分泌性免疫球蛋白系统及溶菌酶的免疫过氧化物酶研究
Gut. 1982 Jul;23(7):578-88. doi: 10.1136/gut.23.7.578.
2
3
The detection and specificity of class specific antibodies to whole bacterial cells using a solid phase radioimmunoassay.使用固相放射免疫测定法检测针对全细菌细胞的类特异性抗体及其特异性。
Clin Exp Immunol. 1983 Jul;53(1):192-200.
4
Human serum antibody response to Campylobacter jejuni infection as measured in an enzyme-linked immunosorbent assay.在酶联免疫吸附测定中检测到的人体血清对空肠弯曲菌感染的抗体反应。
Infect Immun. 1984 May;44(2):292-8. doi: 10.1128/iai.44.2.292-298.1984.
5
Spiral organisms in endoscopic biopsies of the human stomach.人胃内镜活检中的螺旋状生物体。
J Clin Pathol. 1984 Jan;37(1):23-6. doi: 10.1136/jcp.37.1.23.
6
Campylobacter like organisms on the gastric mucosa: culture, histological, and serological studies.胃黏膜上的类弯曲杆菌：培养、组织学及血清学研究
J Clin Pathol. 1984 Sep;37(9):1002-6. doi: 10.1136/jcp.37.9.1002.
7
Specific and nonspecific humoral defense factors in the epithelium of normal and inflamed gastric mucosa. Immunohistochemical localization of immunoglobulins, secretory component, lysozyme, and lactoferrin.正常和炎症性胃黏膜上皮中的特异性和非特异性体液防御因子。免疫球蛋白、分泌成分、溶菌酶和乳铁蛋白的免疫组织化学定位。
Gastroenterology. 1984 Mar;86(3):402-12.
8
Campylobacter-like organisms in the stomach of patients and healthy individuals.患者及健康个体胃中的类弯曲杆菌生物体。
Lancet. 1984 Jun 16;1(8390):1348-9.
9
Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.胃炎和消化性溃疡患者胃内不明弯曲杆菌。
Lancet. 1984 Jun 16;1(8390):1311-5. doi: 10.1016/s0140-6736(84)91816-6.
10
Spiral bacteria of the gastric antrum.胃窦螺旋菌
Lancet. 1984 May 12;1(8385):1068-9. doi: 10.1016/s0140-6736(84)91469-7.
Zotero 插件