Wang X, Zheng S, Zhang H
Institute of Basic Medical Sciences, CAMS, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1994 Oct;16(5):323-7.
Clinical investigation revealed that 75.6% (68/90) of sericulture workers examined had allergic respiratory symptoms. Of the 90 workers, 14 (15.6%) suffered from occupational asthma. Work-related allergens including silkworm cocoon (SC), silkworm urine (SU), moth excrete (ME) and moth scales (MS) were collected and prepared. Serum specific IgE levels were detected by ELISA. The results showed that the level of sIgE in asthmatic workers was significantly higher than that in the "common symptom" group, asymptomatic group and control group. No significant difference in total IgE was found between the workers and controls. The anti-SU-sIgE positive rate was significantly higher than those of sIgE to the other three allergens. These results indicate that the high levels of sIgE are responsible for occupational asthma in sericulture workers and that SU is an important allergen in these patients.
临床调查显示，接受检查的养蚕工人中有75.6%（68/90）出现过敏性呼吸道症状。在这90名工人中，14人（15.6%）患有职业性哮喘。收集并制备了与工作相关的过敏原，包括蚕茧（SC）、蚕尿（SU）、蛾排泄物（ME）和蛾鳞片（MS）。采用酶联免疫吸附测定法检测血清特异性IgE水平。结果显示，哮喘工人的sIgE水平显著高于“常见症状”组、无症状组和对照组。工人与对照组之间的总IgE未发现显著差异。抗SU-sIgE阳性率显著高于针对其他三种过敏原的sIgE阳性率。这些结果表明，sIgE水平升高是养蚕工人职业性哮喘的原因，且SU是这些患者的重要过敏原。
