Stein A D, Ravelli A C, Lumey L H
Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, The Netherlands.
Hum Biol. 1995 Feb;67(1):135-50.
Data from the Dutch Famine Birth Cohort Study were analyzed to assess the influence of acute famine on the relation of maternal weight gain to birth weight, length, and ponderal index. Records were examined for 734 women receiving at least one month of prenatal care and delivering live-born singleton females at the University of Amsterdam Teaching Hospital between August 1944 and April 1946. This period preceded, encompassed, and followed the Hunger Winter, a severe famine. After adjusting for covariates, weight loss or low to moderate (< or = 0.5 kg/week) weight gain was strongly associated with (p < 0.001 for each model) with offspring birth weight, length, and ponderal index and with trimester of famine exposure. At weight gains greater than 0.5 kg/week further weight gain was not associated with birth size. Among women losing weight or gaining < or = 0.5 kg/week the association between third-trimester weight change and birth weight among mother-daughter pairs exposed to famine in early or mid-pregnancy was stronger than the association observed among the unexposed cohort or among those exposed only late in pregnancy. Our results suggest that acute maternal nutritional deprivation affects fetal growth only below a threshold and that, conversely, even after a famine period offspring birth size does not respond in a linear fashion to ad libitum maternal feeding.
对荷兰饥荒出生队列研究的数据进行了分析，以评估急性饥荒对母亲体重增加与出生体重、身长和 ponderal 指数之间关系的影响。研究了 1944 年 8 月至 1946 年 4 月期间在阿姆斯特丹大学教学医院接受至少一个月产前护理并分娩活产单胎女性的 734 名妇女的记录。这段时期在“饥饿冬天”（一场严重饥荒）之前、期间和之后。在对协变量进行调整后，体重减轻或低至中度（≤0.5 千克/周）的体重增加与（每个模型的 p < 0.001）后代出生体重、身长和 ponderal 指数以及饥荒暴露的孕期显著相关。在体重增加大于 0.5 千克/周时，进一步的体重增加与出生大小无关。在体重减轻或增加≤0.5 千克/周的女性中，孕早期或中期暴露于饥荒的母女对中，孕晚期体重变化与出生体重之间的关联比未暴露队列或仅在孕晚期暴露的队列中观察到的关联更强。我们的结果表明，母亲急性营养剥夺仅在低于阈值时影响胎儿生长，相反，即使在饥荒期之后，后代出生大小对母亲随意进食也不会以线性方式做出反应。
