Van Wuyckhuyse B C, Perinpanayagam H E, Bevacqua D, Raubertas R F, Billings R J, Bowen W H, Tabak L A
Department of Dental Research, University of Rochester, NY 14642, USA.
J Dent Res. 1995 Feb;74(2):686-90. doi: 10.1177/00220345950740021001.
We determined the free-amino acid content of stimulated parotid (ductal) saliva from two groups of adult subjects whose caries experiences were markedly different. The levels of free arginine and free lysine in the parotid saliva of caries-free adults were significantly higher than those found in the parotid saliva of individuals with a history of dental decay. There was no correlation, however, between the levels of these amino acids and the DMFS score within the caries-susceptible groups. Microbial catabolism of dibasic amino acids contributes to the neutralization of plaque acids and may partially account for the higher resting plaque pH observed in caries-free subjects. Alternatively, the elevations observed in free levels of arginine and lysine may reflect a systemic alteration in amino acid metabolism which is common to the caries-free group of subjects.
我们测定了两组龋齿经历明显不同的成年受试者受刺激腮腺（导管）唾液中的游离氨基酸含量。无龋成年人腮腺唾液中游离精氨酸和游离赖氨酸的水平显著高于有龋齿病史个体的腮腺唾液中的水平。然而，在龋齿易感组中，这些氨基酸的水平与DMFS评分之间没有相关性。二元氨基酸的微生物分解代谢有助于菌斑酸的中和，并且可能部分解释了在无龋受试者中观察到的较高的静息菌斑pH值。或者，精氨酸和赖氨酸游离水平的升高可能反映了无龋受试者组共有的氨基酸代谢的系统性改变。
