Geschwind D H, Iacoboni M, Mega M S, Zaidel D W, Cloughesy T, Zaidel E
Department of Neurology, UCLA School of Medicine, USA.
Neurology. 1995 Apr;45(4):802-8. doi: 10.1212/wnl.45.4.802.
The neuroanatomic substrate of the alien hand syndrome has remained controversial due to the noncircumscribed nature of cerebral injuries present in most cases. There have been few cases studied in which damage was restricted to portions of the body of the callosum, and most of those involved surgical callosotomy for tumors or epilepsy. We report the case of a woman with a transient alien hand syndrome caused by a stroke limited to the middle and posterior portions of the body of the corpus callosum. This case provides supportive evidence for damage to the midbody of the corpus callosum as the anatomic basis of nondominant alien hand syndrome and conforms to a model of interhemispheric motor disconnection as the essential component of this unusual behavioral syndrome. This disconnection can occur with injuries involving interhemispheric premotor and motor fibers traveling in the midportion of the callosum in individuals with left hemisphere dominance for motor activities.
由于大多数病例中脑损伤的范围不明确，异己手综合征的神经解剖学基础一直存在争议。很少有研究病例的损伤局限于胼胝体部分，其中大多数涉及因肿瘤或癫痫而进行的外科胼胝体切开术。我们报告了一例由中风导致的短暂性异己手综合征病例，中风局限于胼胝体中部和后部。该病例为胼胝体中部损伤作为非优势异己手综合征的解剖学基础提供了支持性证据，并符合半球间运动分离模型，该模型是这种异常行为综合征的基本组成部分。这种分离可能发生在运动活动以左半球为主导的个体中，涉及胼胝体中部的半球间运动前和运动纤维的损伤。
