肌萎缩侧索硬化症中的抗磺基葡萄糖醛酸对globoside IgM抗体

Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis.

作者信息

Ben Younes-Chennoufi A, Rozier A, Dib M, Bouche P, Lacomblez L, Mombo N, Ben Simon G, Yu R K, Baumann N, Meininger V

机构信息

INSERM U 134, Salpetriere Hospital, Paris, France.

出版信息

J Neuroimmunol. 1995 Mar;57(1-2):111-5. doi: 10.1016/0165-5728(94)00169-o.

DOI:10.1016/0165-5728(94)00169-o

PMID:7706428

Abstract

We report here our results on IgM anti-sulfated glucuronyl paragloboside (SGPG) antibodies in sera from patients with amyotrophic lateral sclerosis (ALS). Studies by enzyme linked immunosorbent assay on 72 ALS sera showed IgM polyclonal reactivity towards SGPG in 25 cases. The titer was high in 16 cases. Thin-layer chromatography immuno-overlay showed that reactivity with SGPG was associated to reactivity towards GM1 in five cases and to GM1 and GD1b in one case. Anti-SGPG reactivity was not found in controls and in multifocal motor neuropathy with conduction blocks, in contrast to anti-GM1 antibodies. The presence of anti-SGPG antibodies in ALS patients sera raise again the question of autoimmunity in this pathology.

摘要

我们在此报告肌萎缩侧索硬化症（ALS）患者血清中IgM抗硫酸化葡萄糖醛酸对Globoside（SGPG）抗体的研究结果。通过酶联免疫吸附测定法对72份ALS血清进行研究，结果显示25例患者血清中存在针对SGPG的IgM多克隆反应性。其中16例滴度较高。薄层色谱免疫印迹显示，5例患者与SGPG的反应性与对GM1的反应性相关，1例患者与GM1和GD1b的反应性相关。与抗GM1抗体不同，在对照组和伴有传导阻滞的多灶性运动神经病患者中未发现抗SGPG反应性。ALS患者血清中抗SGPG抗体的存在再次引发了这种病理状态下自身免疫性的问题。