Witteman E M, Hopman W P, Becx M C, De Koning R W, Tytgat G N, Janssen A J, Jansen J B
Department of Gastroenterology and Hepatology, St Radboud Hospital Nijmegen, The Netherlands.
Aliment Pharmacol Ther. 1993 Dec;7(6):683-7. doi: 10.1111/j.1365-2036.1993.tb00151.x.
Thirty-three dyspeptic patients with colonization of Helicobacter pylori in the gastric antrum were treated with tripotassium dicitrate bismuthate 120 mg q.d.s. for 28 days and metronidazole 250 mg q.d.s. for 10 days starting on day 19. Five weeks after cessation of this treatment regimen H. pylori was eradicated in 23 patients. In 8 of the remaining 10 patients, H. pylori had become resistant to metronidazole. In this study resistance was significantly associated with smoking habits, but not with age, bacterial load, gastritis score or alcohol consumption.
33例胃窦部幽门螺杆菌定植的消化不良患者接受了枸橼酸铋钾120毫克，每日4次，共28天的治疗，甲硝唑250毫克，每日4次，从第19天开始服用10天。在该治疗方案停止五周后，23例患者的幽门螺杆菌被根除。在其余10例患者中的8例，幽门螺杆菌已对甲硝唑产生耐药性。在本研究中，耐药性与吸烟习惯显著相关，但与年龄、细菌载量、胃炎评分或饮酒无关。
