爱泼斯坦-巴尔病毒EBNA2对CBF1/RBPJκ转录抑制结构域的掩盖作用。
Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.
作者信息
Hsieh J J, Hayward S D
机构信息
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Science. 1995 Apr 28;268(5210):560-3. doi: 10.1126/science.7725102.
Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) is a transcriptional activator that is essential for EBV-driven B cell immortalization. EBNA2 is targeted to responsive promoters through interaction with a cellular DNA binding protein, C promoter binding factor 1 (CBF1). A transcriptional repression domain has been identified within CBF1. This domain also interacts with EBNA2, and repression is masked by EBNA2 binding. Thus, EBNA2 acts by countering transcriptional repression. Mutation at amino acid 233 of CBF1 abolishes repression and correlates with a loss-of-function mutation in the Drosophila homolog Su(H).
爱泼斯坦-巴尔病毒（EBV）核抗原2（EBNA2）是一种转录激活因子，对于EBV驱动的B细胞永生化至关重要。EBNA2通过与细胞DNA结合蛋白C启动子结合因子1（CBF1）相互作用，靶向于反应性启动子。在CBF1内已鉴定出一个转录抑制结构域。该结构域也与EBNA2相互作用，并且抑制作用被EBNA2结合所掩盖。因此，EBNA2通过对抗转录抑制发挥作用。CBF1第233位氨基酸的突变消除了抑制作用，并且与果蝇同源物Su(H)中的功能丧失突变相关。
Zotero 插件