Lievens M M
UCL, Cliniques Universitaires Saint Luc Service de Biochimie Médicale, Bruxelles.
Acta Clin Belg. 1995;50(1):40-5. doi: 10.1080/17843286.1995.11718420.
A new international reference preparation for proteins in human serum has been recently proposed in Europe from the Community Bureau of Reference (Brussels) under the name CRM 470 (Certified Reference Material) and in the United States from the College of American Pathologists under the name RPPHS (Reference Preparation for Proteins in Human Serum). This serum based material offers the opportunity to the laboratories to standardize their serum protein concentrations, and to improve dramatically the transferability of the results from studies to the local working conditions. The International Federation of Clinical Chemistry strongly recommends the use of this preparation by all laboratories. The Belgian Institute of Hygiene and Epidemiology expects an improvement in the agreement of the results of the three proteins (IgA, IgG, CRP) included in its external quality control of the clinical laboratories. These proteins were omitted from the controls of the second semester of 1994, but would reappear in early 1995, after the conversion of the laboratories to the new protein calibrators. Of course, this implies the assignment of new reference ranges for most of the serum proteins, some of them being significantly modified (alpha 1-antitrypsin, haptoglobin, transferrin, C3, IgM). The clinical chemists must inform the physicians of these changes.
最近，欧洲共同体标准局（布鲁塞尔）提议将一种新的人血清蛋白质国际参考制剂命名为CRM 470（认证参考物质），美国病理学家学会则将其命名为RPPHS（人血清蛋白质参考制剂）。这种基于血清的物质为实验室提供了标准化血清蛋白质浓度的机会，并能显著提高研究结果向当地工作条件的可转移性。国际临床化学联合会强烈建议所有实验室使用这种制剂。比利时卫生与流行病学研究所预计，临床实验室外部质量控制中包含的三种蛋白质（IgA、IgG、CRP）的结果一致性将得到改善。这些蛋白质在1994年下半年的质控中被省略，但在实验室转换为新的蛋白质校准物后，将于1995年初重新出现。当然，这意味着要为大多数血清蛋白质指定新的参考范围，其中一些会有显著变化（α1-抗胰蛋白酶、触珠蛋白、转铁蛋白、C3、IgM）。临床化学家必须将这些变化告知医生。
