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本文引用的文献

1
Uptake and intracellular activity of fluconazole in human polymorphonuclear leukocytes.氟康唑在人多形核白细胞中的摄取及细胞内活性
Antimicrob Agents Chemother. 1993 Feb;37(2):187-90. doi: 10.1128/AAC.37.2.187.
2
Clinical pharmacokinetics of fluconazole.氟康唑的临床药代动力学
Clin Pharmacokinet. 1993 Jan;24(1):10-27. doi: 10.2165/00003088-199324010-00002.
3
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 7-1994. A 55-year-old heart-transplant recipient with a tender, enlarged prostate gland.马萨诸塞州总医院病例记录。每周临床病理病例讨论。病例7 - 1994。一名55岁心脏移植受者，前列腺压痛且肿大。
N Engl J Med. 1994 Feb 17;330(7):490-6. doi: 10.1056/NEJM199402173300710.
4
Antibiotic assays in muscle: are conventional tissue levels misleading as indicator of the antibacterial activity?肌肉中的抗生素检测：传统组织水平作为抗菌活性指标是否具有误导性？
Scand J Infect Dis. 1980;12(4):307-9. doi: 10.3109/inf.1980.12.issue-4.12.
5
Involvement of the kidney and prostate in cryptococcosis.隐球菌病累及肾脏和前列腺。
J Urol. 1973 Apr;109(4):695-8. doi: 10.1016/s0022-5347(17)60518-4.
6
Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection.采用大口径毛细管气液色谱法及氮选择性检测法测定氟康唑。
Antimicrob Agents Chemother. 1989 May;33(5):714-6. doi: 10.1128/AAC.33.5.714.
7
Persistent Cryptococcus neoformans infection of the prostate after successful treatment of meningitis. California Collaborative Treatment Group.
Ann Intern Med. 1989 Jul 15;111(2):125-8. doi: 10.7326/0003-4819-111-2-125.
8
Prostatic cryptococcal infection.前列腺隐球菌感染
Ann Intern Med. 1990 Nov 1;113(9):720. doi: 10.7326/0003-4819-113-9-720_1.
9
Combined therapy with fluconazole and flucytosine in murine cryptococcal meningitis.氟康唑与氟胞嘧啶联合治疗小鼠隐球菌性脑膜炎
Antimicrob Agents Chemother. 1991 Apr;35(4):726-9. doi: 10.1128/AAC.35.4.726.
10
Persistence of Cryptococcus neoformans in the prostate: failure of fluconazole despite high doses.新型隐球菌在前列腺中的持续存在：尽管使用高剂量氟康唑仍治疗失败。
J Infect Dis. 1991 Aug;164(2):435-6. doi: 10.1093/infdis/164.2.435.

氟康唑在人前列腺组织中的渗透情况。

Fluconazole penetration into the human prostate.

作者信息

Finley R W, Cleary J D, Goolsby J, Chapman S W

机构信息

Department of Medicine, University of Mississippi Medical Center, Jackson 39216, USA.

出版信息

Antimicrob Agents Chemother. 1995 Feb;39(2):553-5. doi: 10.1128/AAC.39.2.553.

DOI:10.1128/AAC.39.2.553
PMID:7726532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162579/
Abstract

Fluconazole concentrations in the serum and prostate of human volunteers undergoing transurethral resection for benign prostatic hypertrophy were measured. There was a high correlation (r = 0.783) between serum (mean = 6.6 micrograms/ml) and tissue (mean = 1.9 micrograms/g) fluconazole concentrations, and these data were used to construct a model for local tissue concentrations.

摘要

对因良性前列腺增生接受经尿道切除术的人类志愿者的血清和前列腺中的氟康唑浓度进行了测量。血清（平均 = 6.6微克/毫升）和组织（平均 = 1.9微克/克）中的氟康唑浓度之间存在高度相关性（r = 0.783），并且这些数据被用于构建局部组织浓度模型。