Schauer U, Alefsen S, Jäger R, Riedel F, Rieger C H
Universitäts Kinderklinik, Philipps Universität, Marburg.
Arch Dis Child. 1994 Dec;71(6):506-10. doi: 10.1136/adc.71.6.506.
Infants born prematurely are known to display longstanding bronchial hyperreactivity. The mechanism responsible for this is still unclear. Eosinophils are thought to play a central part in the development of bronchial hyperreactivity in asthma. It was the aim of this study to assess the relation of bronchial hyperresponsiveness to potential markers of eosinophilic inflammation in peripheral blood. Eosinophil count, the concentration of serum eosinophilic cationic protein, the capacity of purified eosinophils to generate leukotriene C4, and bronchial reactivity was studied in 24 non-atopic children born prematurely, 12 healthy controls, and 12 children with asthma aged 6 to 9 years. There was no difference in serum concentrations on eosinophil cationic protein and eosinophil counts. However, eosinophils from the 15 formerly preterm infants with significant bronchial hyperreactivity generated significantly higher amounts of leukotriene C4 than normal controls and prematurely born children without bronchial hyperreactivity. Levels of leukotriene C4 in this group were comparable with those obtained with eosinophils from patients with asthma. In contrast with cells from the other groups, eosinophils from the children with bronchial hyperreactivity born prematurely show no enhancement of leukotriene C4 generation on prestimulation with platelet activating factor. It is concluded that bronchial hyperreactivity of children born prematurely is accompanied by the prestimulation of eosinophils.
众所周知，早产婴儿会表现出长期的支气管高反应性。其背后的机制仍不清楚。嗜酸性粒细胞被认为在哮喘患者支气管高反应性的发展中起核心作用。本研究的目的是评估支气管高反应性与外周血嗜酸性粒细胞炎症潜在标志物之间的关系。对24名早产的非特应性儿童、12名健康对照者以及12名6至9岁的哮喘儿童进行了嗜酸性粒细胞计数、血清嗜酸性粒细胞阳离子蛋白浓度、纯化嗜酸性粒细胞产生白三烯C4的能力以及支气管反应性的研究。嗜酸性粒细胞阳离子蛋白的血清浓度和嗜酸性粒细胞计数没有差异。然而，15名有明显支气管高反应性的早产婴儿的嗜酸性粒细胞产生的白三烯C4量明显高于正常对照者和没有支气管高反应性的早产儿童。该组白三烯C4水平与哮喘患者嗜酸性粒细胞产生的水平相当。与其他组的细胞不同，早产的有支气管高反应性儿童的嗜酸性粒细胞在血小板活化因子预刺激后白三烯C4的产生没有增强。研究得出结论，早产儿童的支气管高反应性伴有嗜酸性粒细胞的预刺激。
