Schauer U, Trube M, Jäger R, Gieler U, Rieger C H
Universitäts Kinderklinik, Philipps Universität, Marburg, Germany.
Allergy. 1995 Feb;50(2):126-32. doi: 10.1111/j.1398-9995.1995.tb05068.x.
To assess the relation among eosinophil-related variables in the peripheral blood, bronchial hyperreactivity, and the presence of atopic dermatitis in children aged 5-14 years, we studied 11 patients with atopic dermatitis alone, six with asthma and atopic dermatitis, 12 with asthma alone, and 12 healthy controls. Eosinophil counts, levels of eosinophil cationic protein, and the capacity of eosinophils to generate leukotriene (LT) C4, as well as bronchial hyperreactivity and a severity score for atopic dermatitis, were determined. Eosinophil variables were significantly higher in both patient groups with atopic dermatitis than in normal controls. In particular, ionophore A 23187 LTC4 generation was higher in patients with atopic dermatitis alone (median 82, range 25-273 ng/10(6) cells) and patients with combined asthma and atopic dermatitis (median 68, range 32-583 ng/10(6) cells) than in normal controls (median 9, range 1-67 ng/10(6) cells). However, there was no difference between the group of atopic dermatitis patients with asthma and without asthma. We conclude that eosinophil variables in the peripheral blood are mainly influenced by the presence of atopic dermatitis, and not the presence and the severity of asthma in patients with both asthma and atopic dermatitis.
为了评估5至14岁儿童外周血中嗜酸性粒细胞相关变量、支气管高反应性和特应性皮炎之间的关系，我们研究了11名单纯患有特应性皮炎的患者、6名患有哮喘和特应性皮炎的患者、12名单纯患有哮喘的患者以及12名健康对照者。测定了嗜酸性粒细胞计数、嗜酸性粒细胞阳离子蛋白水平、嗜酸性粒细胞产生白三烯（LT）C4的能力，以及支气管高反应性和特应性皮炎的严重程度评分。两个患有特应性皮炎的患者组中的嗜酸性粒细胞变量均显著高于正常对照组。特别是，单独患有特应性皮炎的患者（中位数82，范围25 - 273 ng/10(6)细胞）和同时患有哮喘和特应性皮炎的患者（中位数68，范围32 - 583 ng/10(6)细胞）中离子载体A 23187诱导的LTC4生成高于正常对照组（中位数9，范围1 - 67 ng/10(6)细胞）。然而，患有哮喘和未患有哮喘的特应性皮炎患者组之间没有差异。我们得出结论，外周血中的嗜酸性粒细胞变量主要受特应性皮炎的影响，而非同时患有哮喘和特应性皮炎患者中哮喘的存在及严重程度的影响。
