Radler S, Blaschke G
Institute of Pharmaceutical Chemistry, University of Münster, Germany.
Arch Pharm (Weinheim). 1995 Feb;328(2):127-9. doi: 10.1002/ardp.19953280207.
Dimethindene and its metabolite N-demethyldimethindene were determined in human urine after dermal administration of dimethindene. The HPLC-method used was previously described. Data of 8 volunteers are presented. After 32 h an average of 0.023% of the administered dose of dimethindene and 0.022% of N-demethyldimethindene were excreted into urine. Since also after oral administration of dimethindene only about 1% of unmetabolised dimethindene is found in urine it can be concluded that a certain amount of dimethindene is absorbed through the skin after dermal administration.
在经皮给予二甲茚定后，对人尿液中的二甲茚定及其代谢物N - 去甲基二甲茚定进行了测定。所使用的高效液相色谱法先前已有描述。文中给出了8名志愿者的数据。32小时后，平均有0.023%的给予剂量的二甲茚定和0.022%的N - 去甲基二甲茚定排泄到尿液中。由于口服二甲茚定后尿液中仅发现约1%未代谢的二甲茚定，因此可以得出结论，经皮给药后一定量的二甲茚定可通过皮肤吸收。
