Mitchell N S, Shepard N
J Bone Joint Surg Am. 1978 Apr;60(3):342-8.
Articular cartilage from thirteen patients with rheumatoid arthritis was studied by both light and electron microscopy using recently developed staining techniques for proteoglycan. Normally proteoglycan is concentrated about active chondrocytes, but in the cartilage from these patients it was found to be diminished about most of the chondrocytes while it was increased around a few. Fragmentation of collagen and phagocytosis of the fragments by chondrocytes were also noted. This dissolution of collagen was associated with loss of proteoglycan in the matrix. These findings are consistent with the variable nature of the rheumatoid destructive process and appear to be morphological reflections of biochemical changes which formerly were thought to occur in this disease only at the cartilage-pannus junction.
利用最近开发的蛋白聚糖染色技术，通过光学显微镜和电子显微镜对13例类风湿性关节炎患者的关节软骨进行了研究。正常情况下，蛋白聚糖集中在活跃的软骨细胞周围，但在这些患者的软骨中，发现大多数软骨细胞周围的蛋白聚糖减少，而少数软骨细胞周围的蛋白聚糖增加。还观察到胶原的碎片化以及软骨细胞对碎片的吞噬作用。这种胶原的溶解与基质中蛋白聚糖的丢失有关。这些发现与类风湿性破坏过程的多变性质一致，似乎是以前认为仅在软骨-血管翳交界处发生的生化变化的形态学反映。
