Page R L, Thrall D E
College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
In Vivo. 1994 Nov-Dec;8(5):851-8.
Dogs with spontaneously arising tumors have contributed greatly to the field of therapeutic hyperthermia. Pharmacologic, physiologic and immunologic characterization of the response to hyperthermia combined with radiation and chemotherapy in dogs has helped in development of new heating methods, warned of significant toxicity prior to human testing, and defined the effect of heat on drug distribution and relative potency. Clinical trials have been conducted in dogs with spontaneously arising cancer to refine treatment protocols prior to human clinical testing and have demonstrated the tumor control advantage of combined radiation/hyperthermia compared to radiation only in numerous prospective, phase III trials. These studies can be conducted less expensively and more rapidly than comparable studies in humans. This paradigm demonstrates the value of an intermediate, clinically relevant model in the study of novel treatment strategies and should continue to be used to investigate important issues for the benefit of both humans and animals with cancer.
患有自发性肿瘤的犬类对治疗性热疗领域做出了巨大贡献。对犬类进行热疗联合放疗和化疗反应的药理学、生理学和免疫学特征研究，有助于开发新的加热方法，在人体试验前就警示了显著的毒性，并明确了热对药物分布和相对效力的影响。在患有自发性癌症的犬类中进行了临床试验，以在人体临床试验前完善治疗方案，并且在众多前瞻性III期试验中证明了联合放疗/热疗相较于单纯放疗在肿瘤控制方面的优势。这些研究比在人类中进行的类似研究成本更低、速度更快。这种模式证明了在新型治疗策略研究中使用具有临床相关性的中间模型的价值，并且应该继续用于研究重要问题，以造福患癌的人类和动物。
