Gilbert R E, Stanford M R, Jackson H, Holliman R E, Sanders M D
Department of Epidemiology and Biostatistics, Institute of Child Health, London.
BMJ. 1995 Apr 22;310(6986):1037-40. doi: 10.1136/bmj.310.6986.1037.
To determine the incidence of acute symptomatic toxoplasma retinochoroiditis presenting to ophthalmologists for patients born in Britain and elsewhere.
Population based, cross sectional study.
11 districts in south Greater London.
All patients presenting to NHS ophthalmologists with symptoms due to acute toxoplasma retinochoroiditis in 1992-3.
Intraocular inflammation in association with a retinochoroidal scar, active adjoining retinitis, and IgG serum antibodies to toxoplasma.
The estimated incidence of acute symptomatic retinochoroiditis for all people born in Britain was 0.4/100,000/year. If a mean of two symptomatic episodes per lifetime is assumed, 100 people born in Britain may be affected each year, about a fifth of the estimated 500-600 congenitally infected people born each year.
A substantial proportion of people with acute symptomatic toxoplasma retinochoroiditis were born outside the country, and the number born in Britain was smaller than the number previously estimated to develop retinochoroidal lesions due to congenital toxoplasmosis. These findings suggest that prenatal screening for toxoplasmosis in Britain may be of limited benefit.
确定在英国及其他地区出生的患者中，因急性症状性弓形虫视网膜脉络膜炎而就诊于眼科医生的发病率。
基于人群的横断面研究。
大伦敦南部的11个区。
1992年至1993年间因急性弓形虫视网膜脉络膜炎症状而就诊于英国国家医疗服务体系（NHS）眼科医生的所有患者。
与视网膜脉络膜瘢痕相关的眼内炎症、活跃的相邻视网膜炎症以及针对弓形虫的IgG血清抗体。
所有在英国出生的人的急性症状性视网膜脉络膜炎估计发病率为每年0.4/10万。如果假设每人一生平均有两次症状发作，那么每年可能有100名在英国出生的人受到影响，约占每年估计的500 - 600名先天性感染人群的五分之一。
相当一部分有急性症状性弓形虫视网膜脉络膜炎的人出生在国外，在英国出生的人数比之前估计的因先天性弓形虫病而发生视网膜脉络膜病变的人数要少。这些发现表明，英国对弓形虫病进行产前筛查可能益处有限。
