La Vecchia C, Ferraroni M, D'Avanzo B, Franceschi S, Decarli A, Baron J A
Istituto di Statistica Medica Biometria e, Università di Milano, Italy.
Eur J Cancer Prev. 1995 Feb;4(1):69-72. doi: 10.1097/00008469-199502000-00006.
The number of siblings is an indirect indicator of living and, possibly, dietary conditions in childhood and adolescence. The relationship between the number of siblings and subsequent gastric cancer risk was analysed using data from a case--control study conducted in Italy between 1985 and 1992 on 723 cases of incident, histologically confirmed gastric cancer and 2,024 controls in hospital for acute, non-neoplastic, non-digestive tract disorders. After allowance for age and sex, there was a significant trend of increasing gastric cancer risk with increasing number of siblings (P < 0.01). Compared with subjects with no siblings, the relative risk (RR) was 1.1 for those with one, 1.3 for 2, 1.4 for 3-6 and 1.7 for 7 or more siblings. The association was stronger in subjects above the age of 60: the RR for > or = 5 siblings was 1.8, as compared with 1.2 for younger subjects. These patterns of trends are consistent with the hypothesis that domestic crowding and deprivation in childhood and adolescence is a correlate of subsequent gastric cancer risk, and offer therefore interesting clues to our understanding of the process of gastric carcinogenesis.
兄弟姐妹的数量是童年和青少年时期生活状况以及可能的饮食状况的一个间接指标。利用1985年至1992年在意大利进行的一项病例对照研究的数据，分析了兄弟姐妹数量与后续患胃癌风险之间的关系。该研究涉及723例新发病例、经组织学确诊的胃癌患者以及2024名因急性非肿瘤性非消化道疾病住院的对照者。在考虑年龄和性别因素后，随着兄弟姐妹数量的增加，患胃癌的风险呈现出显著的上升趋势（P < 0.01）。与没有兄弟姐妹的受试者相比，有1个兄弟姐妹的受试者相对风险（RR）为1.1，有2个为1.3，有3 - 6个为1.4，有7个或更多兄弟姐妹的为1.7。这种关联在60岁以上的受试者中更强：有≥5个兄弟姐妹的RR为1.8，而较年轻受试者为1.2。这些趋势模式与童年和青少年时期家庭拥挤和贫困是后续患胃癌风险的一个相关因素这一假设相一致，因此为我们理解胃癌发生过程提供了有趣的线索。
