[18F]氟代脱氧葡萄糖正电子发射断层显像（PET）在强迫症中的研究。治疗后的临床/代谢相关性研究。
[18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment.
作者信息
Perani D, Colombo C, Bressi S, Bonfanti A, Grassi F, Scarone S, Bellodi L, Smeraldi E, Fazio F
机构信息
Istituto di Neuroscienze and Bioimmagini CNR. c/o H San Raffaele, Milan, Italy.
出版信息
Br J Psychiatry. 1995 Feb;166(2):244-50. doi: 10.1192/bjp.166.2.244.
BACKGROUND
We used [18F]FDG and PET in patients with obsessive-compulsive disorder (OCD) to evaluate cerebral metabolic involvement before and after treatment with serotonin-specific reuptake inhibitors.
METHOD
In 11 untreated, drug-free adults, regional cerebral metabolic rate for glucose (rCMRglu) was compared with that of 15 age-matched normal controls.
RESULTS
rCMRglu values were significantly increased in the cingulate cortex, thalamus and pallidum/putamen complex. After treatment a significant improvement in obsessive-compulsive symptoms on the Y-BOC scale (t = 3.59, P < 0.01) was associated with a significant bilateral decrease of metabolism in the whole cingulate cortex (P < 0.001). Clinical and metabolic data were significantly intercorrelated (Kendall's tau = 0.65; P < 0.01).
CONCLUSIONS
These findings indicate that OCD is associated with functional hyperactivity of a selected neuronal network and that treatment to reduce symptoms may have a selective neuromodulatory effect on cingulate cortex.
背景
我们使用[18F]氟脱氧葡萄糖（[18F]FDG）和正电子发射断层扫描（PET）对强迫症（OCD）患者进行研究，以评估血清素特异性再摄取抑制剂治疗前后大脑代谢的变化情况。
方法
选取11名未经治疗且未服用药物的成年患者，将其大脑葡萄糖区域代谢率（rCMRglu）与15名年龄匹配的正常对照者进行比较。
结果
扣带回皮质、丘脑以及苍白球/壳核复合体的rCMRglu值显著升高。治疗后，耶鲁-布朗强迫症量表（Y-BOC）上强迫症症状有显著改善（t = 3.59，P < 0.01），同时整个扣带回皮质的代谢显著双侧下降（P < 0.001）。临床和代谢数据显著相关（肯德尔等级相关系数tau = 0.65；P < 0.01）。
结论
这些发现表明，强迫症与特定神经网络的功能亢进有关，减轻症状的治疗可能对扣带回皮质有选择性的神经调节作用。
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