Kitagawa I, Mahmud T, Kobayashi M, Shibuya H
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Chem Pharm Bull (Tokyo). 1995 Feb;43(2):365-7. doi: 10.1248/cpb.43.365.
Through bioassay-guided separation of the chemical constituents of the needles of Taxus sumatrana, taxol (1), cephalomannine (2), and a new taxoid 19-hydroxy-13-oxobaccatin III (8) have been isolated together with 7-epi-10-deacetyltaxol (3), 7-epi-10-deacetylcephalomannine (4), baccatin III (5), 19-hydroxybaccatin III (6), and 10-deacetyl-13-oxobaccatin III (7). The chemical structure of 8 has been elucidated on the bases of its chemical and physicochemical properties.
通过对苏门答腊红豆杉针叶化学成分进行生物测定导向分离，已分离得到紫杉醇（1）、三尖杉宁碱（2）和一种新的紫杉烷类化合物19-羟基-13-氧代巴卡亭III（8），以及7-表-10-去乙酰紫杉醇（3）、7-表-10-去乙酰三尖杉宁碱（4）、巴卡亭III（5）、19-羟基巴卡亭III（6）和10-去乙酰-13-氧代巴卡亭III（7）。已根据其化学和物理化学性质阐明了8的化学结构。
