Vander Velde D G, Georg G I, Gollapudi S R, Jampani H B, Liang X Z, Mitscher L A, Ye Q M
Department of Medicinal Chemistry, University of Kansas, Lawrence 66045-2506.
J Nat Prod. 1994 Jun;57(6):862-7. doi: 10.1021/np50108a032.
A new taxoid, wallifoliol [3], has been isolated, along with five known taxoids (taxol, cephalomannine, 10-deacetylbaccatin III, brevifoliol, 2-acetoxy brevifoliol = taxchinin A) from extracts of the needles of Himalayan Taxus wallichiana. The structure of wallifoliol has been assigned primarily from nmr studies. Wallifoliol [3] is assigned a structure in which rings A and B of the taxane system have undergone putative rearrangements producing a novel skeleton. Wallifoliol is the first diterpene to be found in nature with this particular 5/6/6/6/4 ring system.
